901575

t-Boc-N-amido-PEG₃-CH₂CO₂H

≥95%

• Empirical Formula (Hill Notation): C₁₃H₂₅NO₇
• CAS Number: 462100-06-7
• Molecular Weight: 307.34
• MDL number: MFCD22376773
• UNSPSC Code: 51171641
• NACRES: NA.22

Properties

• assay: ≥95%
• form: liquid
• reaction suitability: reagent type: linker
• functional group: Boc; amine; carboxylic acid
• storage temp.: −20°C
• SMILES string: OC(COCCOCCOCCNC(OC(C)(C)C)=O)=O
• InChI: 1S/C13H25NO7/c1-13(2,3)21-12(17)10(14)8-19-6-4-18-5-7-20-9-11(15)16/h10H,4-9,14H2,1-3H3,(H,15,16)
• InChI key: FUUVHHQEYXVKFA-UHFFFAOYSA-N

Description

Application

This is a crosslinker with a t-Boc protected amine on one end and a carboxyl group on the other end. The compound contains three PEG units to help improve solubility.

t-Boc-N-amido-PEG₃-CH₂CO₂H is a heterobifunctional, PEGylated crosslinker featuring a Boc-protected amine at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. t-Boc-N-amido-PEG₃-CH₂CO₂H can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3