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908843

Sigma-Aldrich

Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide)

average Mn (1,600-1,500-1,600), lactide:glycolide 75:25

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Synonym(s):
PLGA-PEG-PLGA
Linear Formula:
H((C3H4O2)x(C2H2O2)y)m((C2H4O)z)nO((C3H4O2)x(C2H2O2)y)mH

form

semisolid

feed ratio

lactide:glycolide 75:25

mol wt

PEG average Mn 1,500 (by NMR)
PLGA average Mn 3,200 (by NMR)
average Mn (1,600-1,500-1,600)

color

white to tan

PDI

≤2.0
<1.1 (Typical PEG PDI )

storage temp.

−20°C

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This Item
900664913138911429
storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

feed ratio

lactide:glycolide 75:25

feed ratio

-

feed ratio

lactide:glycolide 50:50

feed ratio

lactide:glycolide 80:20

mol wt

PEG average Mn 1,500 (by NMR)

mol wt

-

mol wt

PEG average Mn 2,000, PLGA average Mn 10,000 (by NMR)

mol wt

PEG average Mn 5,000 (by NMR), PLGA average Mn 5,000 (by NMR)

color

white to tan

color

-

color

white to beige

color

white

PDI

≤2.0

PDI

-

PDI

-

PDI

-

Application

PLGA-PEG-PLGA is an amphiphilic triblock copolymer which can self-assemble into micelles in aqueous medium due to the hydrophobic interactions present in the hydrophobic segments. The PEG segment imparts hydrophilicity and improves the biocompatibility of the copolymer. The PLGA segment forms a hydrophobic core and can solubilize hydrophobic drugs. These copolymers are widely used as nanocarriers for the sustained release of drugs. Also this polymer exhibits thermogelation behavior. When applied in biomedical applications, the temperature responsive nature of the copolymer can be tuned to induce an in situ gelation at physiological temperature to provide controlled drug release. These materials have been explored for biomedical applications as temperature-responsive biodegradable systems for drug delivery, tissue engineering and wound healing.

Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Thermoreversible Gelation of PEG-PLGA-PEG Triblock Copolymer Aqueous Solutions.
Jeong B, et al.
Macromolecules, 32(21), 7064-7069 (1999)
Chayanin Pratoomsoot et al.
Biomaterials, 29(3), 272-281 (2007-11-03)
Ocular trauma and disorders that lead to corneal blindness account for over 2 million new cases of monocular blindness every year. A popular ocular surface reconstruction therapy, amniotic membrane transplantation, has been shown to aid corneal wound repair. However, the
Mingxi Qiao et al.
Die Pharmazie, 61(3), 199-202 (2006-04-08)
Biodegradable thermosensitive poly (DL-lactide-co-glycolide-b-ethylene glycol-b-DL-lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymers with DL-lactide/glycolide molar ratio ranging from 6/1 to 15/1 were synthesized from monomers of DL-lactide, glycolide and polyethylene glycol and were evaluated for sustained release of bee venom peptide in vitro. The
Jun Ge et al.
ACS nano, 6(1), 227-233 (2011-11-25)
We describe a new temperature and electric field dual-stimulus responsive nanoparticle system for programmed drug delivery. Nanoparticles of a conducting polymer (polypyrrole) are loaded with therapeutic pharmaceuticals and are subcutaneously localized in vivo with the assistance of a temperature-sensitive hydrogel
Byeongmoon Jeong et al.
Biomacromolecules, 3(4), 865-868 (2002-07-09)
This paper reports on the thermogelling, biodegradable polymer formulations based on poly(DL-lactic acid-co-glycolic acid)/(poly(ethylene glycol) graft copolymers for in vivo biomedical applications using animal models. The description includes diabetic control by sustained insulin delivery and cartilage repair by chondrocyte cell

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