914924

3-[2-N-(Biotinyl)aminoethyldithio]propanoic acid

≥95%

• Synonym(s): 3-((2-(5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethyl)disulfaneyl)propanoic acid, Biotin-SS-COOH, Cleavable biotin linker
• Empirical Formula (Hill Notation): C₁₅H₂₅N₃O₄S₃
• CAS Number: 104582-29-8
• Molecular Weight: 407.57
• MDL number: MFCD04039425
• UNSPSC Code: 12352106
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: ≥95%
• form: powder
• mp: 172-175 °C
• storage temp.: −20°C
• SMILES string: S1[C@H]([C@H]2NC(=O)N[C@H]2C1)CCCCC(=O)NCCSSCCC(=O)O
• InChI: 1S/C15H25N3O4S3/c19-12(16-6-8-25-24-7-5-13(20)21)4-2-1-3-11-14-10(9-23-11)17-15(22)18-14/h10-11,14H,1-9H2,(H,16,19)(H,20,21)(H2,17,18,22)/t10-,11-,14-/m0/s1
• InChI key: LUKYYZVIDAWYMZ-MJVIPROJSA-N

Description

Application

3-[2-N-(Biotinyl)aminoethyldithio]propanoic acid (Biotin-SS-COOH) is a cleavable, biotinylated crosslinkers. The linker can also be used for synthesis of chemical biology tools for labeling target proteins in biological experiments and assays. It possesses dual functionality: enrichment via the biotin and an embedded disulfide bridge for cleavage under reducing conditions.

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Other Notes

Uniformly Cationized Protein Efficiently Reaches the Cytosol of Mammalian Cells

A Mechanism-Based ICAT Strategy for Comparing Relative Expression and Activity Levels of Glycosidases in Biological Systems

Dissociation-independent selection of high-affinity anti-hapten phage antibodies using cleavable biotin-conjugated haptens

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable