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918075

Sigma-Aldrich

NanoFabTx PLA-nano

for synthesis of 100 and 200 nm particles

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Synonym(s):
For nanoparticle synthesis for drug delivery

Quality Level

application(s)

advanced drug delivery

storage temp.

2-8°C

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917796915408909637
NanoFabTx™ PLA-nano for synthesis of 100 and 200 nm particles

Sigma-Aldrich

918075

NanoFabTx PLA-nano

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

application(s)

advanced drug delivery

application(s)

advanced drug delivery

application(s)

advanced drug delivery

application(s)

advanced drug delivery

General description

The NanoFabTx Polymer drug formulation kit, PLA, for synthesis of 100 and 200 nm particles is a ready-to-use nanoformulation kit for the synthesis of drug-encapsulating PLA-based nanoparticles. This kit provides properly selected PLA based polymers, stabilizer, and protocols for fabrication of PLA nanoparticles by both nanoprecipitation and microfluidic-based synthesis. The microfluidics protocol uses a NanoFabTx device kits (911593, sold separately), which provide all the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).Comprehensive protocols for two different particle synthesis methods are included:

  • A nanoprecipitation protocol to prepare drug-encapsulated nanoparticles in standard laboratory glassware.
  • A microfluidics protocol using commercial platforms or syringe pumps.

Application

The NanoFabTx Polymer drug formulation kit, PLA, for synthesis of 100 and 200 nm particles enables users to encapsulate a wide variety of therapeutic drug molecules in PLA-based nanoparticles. Drug encapsulated nanoparticles synthesized with the NanoFabTx kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, antigen delivery, and vaccine delivery. Poly(D,L-lactic acid) (PLA) is a biocompatible and biodegradable polymer that has been approved by the FDA for biomedical and pharmaceutical applications. Because of their robust mechanical properties and slow degradation, PLA based nanoparticles have been widely used as drug delivery systems to achieve controlled drug release for different types of therapeutic molecules. This kit minimizes laboratory setup with optimized protocols and step-by-step instruction for synthesizing drug-encapsulated nanoparticle-based formulations. It is designed to help pharmaceutical researches achieve reproducible synthesis with high loading efficiencies without the need for lengthy trial-and-error optimization.

Features and Benefits

  • Ready-to-use nanoformulation kit for PLA nanoparticles
  • Step-by-step protocols developed and tested by our formulation scientists
  • Flexible synthesis tool to create uniform and reproducible nanoparticles
  • Optimized to make nanoparticles 100–200 nm nanoprecipitation or microfluidics with low polydispersity
  • Based on non-toxic, biodegradable polymers

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


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S Freiberg et al.
International journal of pharmaceutics, 282(1-2), 1-18 (2004-09-01)
Polymer microspheres can be employed to deliver medication in a rate-controlled and sometimes targeted manner. Medication is released from a microsphere by drug leaching from the polymer or by degradation of the polymer matrix. Since the rate of drug release
C Thomasin et al.
Journal of pharmaceutical sciences, 87(3), 269-275 (1998-04-02)
Phase separation (frequently called coacervation) of poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA) is a classical method for drug microencapsulation. Here, attempts have been made to describe this process in the light of thermodynamics. Different PLA/PLGAs were dissolved in either dichloromethane or
K S Soppimath et al.
Journal of controlled release : official journal of the Controlled Release Society, 70(1-2), 1-20 (2001-02-13)
This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems. Methods of preparation, drug loading and drug release are covered. The most important findings on surface modification methods as well as
Robert F Pagels et al.
Journal of controlled release : official journal of the Controlled Release Society, 219, 519-535 (2015-09-12)
Biologically derived therapeutics, or biologics, are the most rapidly growing segment of the pharmaceutical marketplace. However, there are still unmet needs in improving the delivery of biologics. Injectable polymeric nanoparticles and microparticles capable of releasing proteins and peptides over time
Verónica Lassalle et al.
Macromolecular bioscience, 7(6), 767-783 (2007-06-02)
The controlled release of medicaments remains the most convenient way of drug delivery. Therefore, a wide variety of reports can be found in the open literature dealing with drug delivery systems. In particular, the use of nano- and microparticles devices

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Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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