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918881

Sigma-Aldrich

NanoFabTx PEG-PCL drug formulation screening kit

for synthesis of PEGylated nanoparticles

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Synonym(s):
Drug delivery reagent kit, NanoFabTx reagent kit, Nanoparticle synthesis kit, PEG-PCL

description

Drug loading screening kit, for synthesis of PEGylated PCL nanoparticles
Kit components :
PEGPCL-L(915203-500mg)
PEGPCL-H(912549-500mg)
PEGPCL-UH (917788-500mg)
Stabilizer-Nano (907766-5g)

Quality Level

application(s)

advanced drug delivery

storage temp.

2-8°C

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917796915408909637
Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

description

Drug loading screening kit, for synthesis of PEGylated PCL nanoparticles

description

Drug loading screening kit, for synthesis of PEGylated PLGA nanoparticles, Kit components :
PEGPLGA-50L(912808-500mg)
PEGPLGA-75L(913049-500mg)
PEGPLGA-50H (915955-500mg)
PEGPLGA-75H (915718-500mg)
Stabilizer-Nano (907766-5g)

description

Kit components :
PEGPLGA-50L (912808-500mg)
PEGPLGA-75L (913049-500mg)
PEGPLA-L (913308-500mg)
PEGPCL-H (912549-500mg)
Stabilizer - P (913448-10g), Materials screening kit, for synthesis of PEGylated polymeric nanoparticles

description

PLGA nanoparticle screening kit for synthesis of 100 and 200 nm particles

application(s)

advanced drug delivery

application(s)

advanced drug delivery

application(s)

advanced drug delivery

application(s)

advanced drug delivery

General description

NanoFabTx PEG-PCL drug loading screening kit is a ready-to-use nanoformulation kit for the synthesis of PEGylated PCL nanoparticles 50 to 130 nm in size. This kit provides properly selected PEGylated PCL polymers, stabilizer, and protocols for the synthesis of drug-encapsulating nanoparticles by nanoprecipitation and microfluidic methods. Three different PEGylated PCLs are included in this kit, allowing rapid screening of optimal materials for enhancing drug loading. Protocols for two different particle synthesis methods are included.
  • A Nanoprecipitation protocol to prepare drug-encapsulated nanoparticles in standard laboratory glassware.
  • A Microfluidics protocol using commercial platforms or syringe pumps.
The microfluidics protocol uses NanoFabTx device kits (911593, sold separately), which provide all the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Application

NanoFabTx nanoformulation reagent kits enable users to encapsulate a wide variety of therapeutic drug molecules for targeted or extended drug delivery without the need for lengthy trial-and-error optimization. Drug encapsulated particles synthesized with the NanoFabTx kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delivery. Poly (ethylene glycol)-block-poly(caprolactone) (PEG-PCL) is a biocompatible and biodegradable polymer that has been approved by the FDA and the EMA for biomedical and pharmaceutical applications. PEG-PCL based nanoparticles have been widely used as drug delivery systems for different types of therapeutic molecules, to achieve controlled drug release. PEG-PCL nanoparticles offer a slow degradation rate, ideal for long-term implantation and sustained release. And unlike other polymer materials, PEG-PCL does not produce acidic byproducts upon degradation.

Features and Benefits

  • Ready-to-use nanoformulation kit for PEGylated PCL nanoparticles
  • Choose from either nanoprecipitation or microfluidics-based protocols
  • Create specifically sized, biodegradable, PEGylated PCL nanoparticles
  • Maximize the encapsulation of hydrophobic drugs
  • Three different PEGylated PCLs are included

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 3


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Functionalized Solid-Sphere PEG-b-PCL Nanoparticles to Target Brain Capillary Endothelial Cells In Vitro.
Grossen P, et al.
Journal of Nanomaterials (2016)
Rutian Li et al.
International journal of pharmaceutics, 379(1), 158-166 (2009-06-16)
To establish a satisfactory delivery system for local delivery of Tetradrine (Tet), four kinds of core-shell nanoparticles were prepared from di-block copolymer of methoxy poly(ethylene glycol)-polycaprolactone (MePEG-PCL) and tri-block copolymer of polycaprolactone-poly(ethylene glycol)-polycaprolactone (PCL-PEG-PCL). The physiochemical traits of the four
MaLing Gou et al.
Current drug targets, 12(8), 1131-1150 (2011-03-30)
Nanotechnology provides researchers with new tools for cancer treatment. Biodegradable polymeric nanoparticles, as an advanced drug delivery system, have promising applications in cancer treatment. Poly(ε-caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymers are biodegradable and amphiphilic, and show potential application in drug delivery. In
Yong Hu et al.
Journal of controlled release : official journal of the Controlled Release Society, 118(1), 7-17 (2007-01-24)
Core-shell nanoparticles were prepared from di-block copolymer of methoxy poly(ethylene glycol)-polycaprolactone (MePEG-PCL) and tri-block copolymer of polycaprolactone-poly(ethylene glycol)-polycaprolactone (PCL-PEG-PCL). The MePEG-PCL copolymers form nanoparticles with PEG "brush" on their surfaces and PCL-PEG-PCL copolymers form nanoparticles with a "mushroom-like" structure on
MPEG−PCL copolymeric nanoparticles in drug delivery systems.
Hossein D, et al.
Cogent medicine., 3(1) (2016)

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