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925217

Sigma-Aldrich

TissueFab® - low endotoxin GelMA-UV bioink

0.2 μm filtered, suitable for 3D bioprinting applications

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Synonym(s):
Bioink, GelMA, Gelatin methacrylamide, Gelatin methacrylate, Gelatin methacryloyl

Quality Level

100

sterility

0.2 μm filtered

form

viscous liquid (to gel)

size

10 mL

impurities

≤5 CFU/g

Bioburden

(Fungal)
≤5 CFU/g Bioburden (Aerobic)
≤50 EU/mL Endotoxin

color

pale yellow to colorless

pH

6.5-7.5

viscosity

2-20 cP

application(s)

3D bioprinting

storage temp.

2-8°C

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TissueFab® bioink Alg(Gel)ma -UV/365 nm

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form

viscous liquid (to gel)

form

viscous liquid (gel)

form

viscous liquid (gel)

form

viscous liquid (gel)

size

10 mL

size

-

size

-

size

10 mL

impurities

≤5 CFU/g

Bioburden

(Fungal)

impurities

<5 cfu/mL Bioburden, <50 EU/mL Endotoxin

impurities

<5 CFU/g Bioburden (Total Aerobic), <5 CFU/g Bioburden (fungal), <50 EU/mL Endotoxin

impurities

<5 cfu/mL Bioburden, <50 EU/mL Endotoxin

color

pale yellow to colorless

color

pale yellow to colorless

color

pale yellow to colorless

color

pale yellow to colorless

pH

6.5-7.5

pH

6.5-7.5

pH

6.5-7.5

pH

6.5-7.5

General description

Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications.

The addition of photocrosslinkable methacrylamide functional groups in GelMA allows the synthesis of biocompatible, biodegradable, and non-immunogenic hydrogels that are stable in biologically relevant conditions and promote cell adhesion, spreading, and proliferation.

Temporal and spatial control of the crosslinking reaction can be obtained by adjusting the degree of functionalization and polymerization conditions, allowing for the fabrication of hydrogels with unique patterns, 3D structures, and morphologies.

Application

Gelatin methacrylate based bioinks have been used in the following bioprinting applications:

  • osteogenic,
  • chondrogenic ,
  • hepatic ,
  • adipogenic ,
  • vasculogenic ,
  • epithelial ,
  • endothelial ,
  • cardiac valve ,
  • skin ,
  • tumors

Features and Benefits

  • Ready-to-use formulation optimized for high printing fidelity and cell viability, eliminating the lengthy bioink formulation development process
  • Step-by-step protocols developed and tested by MilliporeSigma 3D Bioprinting Scientists, no prior 3D bioprinting experience neede
  • Suitable for different extrusion-based 3D bioprinter model
  • Methacrylamide functional group can also be used to control the hydrogel physical parameters such as pore size, degradation rate, and swell ratio.

Legal Information

TISSUEFAB is a registered trademark of Sigma-Aldrich Co. LLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

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Xiaohong Wang et al.
Polymers, 9(9) (2017-08-30)
Three-dimensional (3D) bioprinting is a family of enabling technologies that can be used to manufacture human organs with predefined hierarchical structures, material constituents and physiological functions. The main objective of these technologies is to produce high-throughput and/or customized organ substitutes
Jun Yin et al.
ACS applied materials & interfaces, 10(8), 6849-6857 (2018-02-07)
Methacrylated gelatin (GelMA) has been widely used as a tissue-engineered scaffold material, but only low-concentration GelMA hydrogels were found to be promising cell-laden bioinks with excellent cell viability. In this work, we reported a strategy for precise deposition of 5%
Christine McBeth et al.
Biofabrication, 9(1), 015009-015009 (2017-01-11)
Due to its relatively low level of antigenicity and high durability, titanium has successfully been used as the major material for biological implants. However, because the typical interface between titanium and tissue precludes adequate transmission of load into the surrounding
Wanjun Liu et al.
Advanced healthcare materials, 6(12) (2017-05-04)
Bioprinting is an emerging technique for the fabrication of 3D cell-laden constructs. However, the progress for generating a 3D complex physiological microenvironment has been hampered by a lack of advanced cell-responsive bioinks that enable bioprinting with high structural fidelity, particularly
Y Shi et al.
Biomedical materials (Bristol, England), 13(3), 035008-035008 (2018-01-09)
Three-dimensional bioprinting is an emerging technology for fabricating living 3D constructs, and it has shown great promise in tissue engineering. Bioinks are scaffold materials mixed with cells used by 3D bioprinting to form a required cell-laden structure. In this paper
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