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930024

Sigma-Aldrich

Hyaluronic acid adipic dihydrazide (HA-ADH)

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Synonym(s):
HA-ADH
Linear Formula:
(C20H33N5O12)n

form

solid (Chunks)

Quality Level

color

white to off-white

application(s)

3D bioprinting

storage temp.

2-8°C

General description

Adipic acid dihydrazide is commonly used as a functional group to allow for HA cross-linking to polymers containing aldehyde groups or that are aldehyde-functionalized, like HA-aldehyde or PEG-aldehyde. These biomaterials are attractive for their tunable properties and low cytotoxicity.
Degree of functionalization (50-80%)

Application

Hyaluronic acid (HA) is a ubiquitous extracellular matrix component, which makes it attractive for use in medical applications for it′s biocompatibility and low immunogenicity. HA-based polymers are used to make hydrogels for a wide variety of applications from tissue engineering and regeneration to drug delivery and bioinks for 3D bioprinting. To make hydrogels, HA has to be derivatized with groups that can cross-link to to other functionalized polymers.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Self-crosslinking and injectable hyaluronic acid/RGD-functionalized pectin hydrogel for cartilage tissue engineering
Chen, et al.
Carbohydrate Polymers, 166, 31-44 (2017)
Xinqiao Jia et al.
Biomacromolecules, 7(12), 3336-3344 (2006-12-13)
Vocal fold scarring disrupts the viscoelastic properties of the lamina propria that are critical for normal phonation. There is a clinical need for the development of advanced biomaterials that approximate the mechanical properties of the lamina propria for in vivo
Yuguo Lei et al.
Biomaterials, 32(1), 39-47 (2010-10-12)
Synthetic hydrogel scaffolds that can be used as culture systems that mimic the natural stem cell niche are of increased importance for stem cell biology and regenerative medicine. These artificial niches can be utilized to control the stem cell fate

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