53747

Hyaluronic acid sodium salt from Streptococcus equi

bacterial glycosaminoglycan polysaccharide

• Synonym(s): Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4]), alternating
• CAS Number: 9067-32-7
• PubChem Substance ID: 24878223
• NACRES: NA.25

Properties

• form: powder or crystals
• mol wt: ~1.5-1.8 x 10E6 Da
• impurities: ≤1% protein
• solubility: H₂O: 5 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: [Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2C([O-])=O
• InChI: 1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1
• InChI key: YWIVKILSMZOHHF-QJZPQSOGSA-N

Description

General description

Hyaluronic acid (HA), a vital component of the extracellular matrix in the central nervous system, is the versatile macromolecule found in the connective tissues of all vertebrates. This supramolecular glycosaminoglycan is a polyanionic natural polymer occurring as a linear polysaccharide. It is made up of glucuronic acid and N-acetylglucosamine repeats through a β-1,4 linkage. HA is seen abundantly in the eyes, joints, and heart valves.

Application

Hyaluronic acid sodium salt from Streptococcus equi has been used:

• with methacrylic anhydride for synthesizing cross-linkable methacrylated HA hydrogel (Coll-MeHA)
• in phosphate buffer saline (PBS) to replace the PBS bath to vary the lubricant composition
• in the preparation of lubricant to study its effects on the boundary lubrication of human osteoarthritis (OA) cartilage

Biochem/physiol Actions

Hyaluronic acid (HA), an important component of synovial fluid and articular cartilage serves as the boundary lubricant. It exhibits several physicochemical properties including biodegradability, biocompatibility, nontoxicity, and nonimmunogenicity. HA is considered a great tool for biomedical uses like drug delivery, tissue engineering, plastic surgery, ocular surgery, and osteoarthritis surgery. It participates in cushioning and lubricating the body. This powerful antioxidant can bond water to tissue.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable