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Hyaluronic acid sodium salt from Streptococcus equi

bacterial glycosaminoglycan polysaccharide

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Synonym(s):
Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4]), alternating
CAS Number:
PubChem Substance ID:
NACRES:
NA.25

biological source

(Streptococcus equi)

Quality Level

form

powder or crystals

mol wt

~1.5-1.8 x 10E6 Da

impurities

≤1% protein

color

white

solubility

H2O: 5 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

[Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2C([O-])=O

InChI

1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1

InChI key

YWIVKILSMZOHHF-QJZPQSOGSA-N

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This Item
736414268640583
color

white

color

white

color

white

color

white

solubility

H2O: 5 mg/mL, clear, colorless

solubility

water: ~5 g/L

solubility

water: ~5 g/L

solubility

water: ~5 g/L

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

biological source

(Streptococcus equi)

biological source

(Streptococcus equi)

biological source

(Streptococcus equi)

biological source

(Streptococcus equi)

mol wt

~1.5-1.8 x 10E6 Da

mol wt

2,000,000-2,400,000

mol wt

30,000-50,000

mol wt

8,000-15,000

General description

Hyaluronic acid (HA), a vital component of the extracellular matrix in the central nervous system, is the versatile macromolecule found in the connective tissues of all vertebrates. This supramolecular glycosaminoglycan is a polyanionic natural polymer occurring as a linear polysaccharide. It is made up of glucuronic acid and N-acetylglucosamine repeats through a β-1,4 linkage. HA is seen abundantly in the eyes, joints, and heart valves.

Application

Hyaluronic acid sodium salt from Streptococcus equi has been used:
  • with methacrylic anhydride for synthesizing cross-linkable methacrylated HA hydrogel (Coll-MeHA)
  • in phosphate buffer saline (PBS) to replace the PBS bath to vary the lubricant composition
  • in the preparation of lubricant to study its effects on the boundary lubrication of human osteoarthritis (OA) cartilage

Biochem/physiol Actions

Hyaluronic acid (HA), an important component of synovial fluid and articular cartilage serves as the boundary lubricant. It exhibits several physicochemical properties including biodegradability, biocompatibility, nontoxicity, and nonimmunogenicity. HA is considered a great tool for biomedical uses like drug delivery, tissue engineering, plastic surgery, ocular surgery, and osteoarthritis surgery. It participates in cushioning and lubricating the body. This powerful antioxidant can bond water to tissue.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Jae-Yong Park et al.
PloS one, 9(11), e112684-e112684 (2014-11-27)
Synovial fluid plays an important role in lubricating synovial joints. Its main constituents are hyaluronic acid (HA) and γ-globulin, acting as boundary lubricants for articular cartilage. The aim of the study was to demonstrate the concentration-dependent effect of HA and
Tao Jin et al.
Biomaterials, 113, 176-190 (2016-11-07)
Extracellular matrix (ECM) is widely used as an inductive biological scaffold to repair soft tissue after injury by promoting functional site-appropriate remodeling of the implanted material. However, there is a lack of non-invasive analysis methods to monitor the remodeling characteristics
Telma E Santos et al.
Cell reports, 32(3), 107907-107907 (2020-07-23)
During development of the central nervous system (CNS), neurons polarize and rapidly extend their axons to assemble neuronal circuits. The growth cone leads the axon to its target and drives axon growth. Here, we explored the mechanisms underlying axon growth
Wei-Yao Chen et al.
Frontiers in endocrinology, 12, 572690-572690 (2021-03-30)
The global obesity population is increasing year-by-year, and the related cost is sharply increasing annually. There are several methods available to combat obesity; however, there is a lack of a single tool that is both safe and efficacious. The use
H C Lin et al.
European cells & materials, 40, 133-145 (2020-09-21)
Vascularisation efficiency plays an essential role in the success of bulk transplantation, while biocompatibility and safety are major concerns in clinical applications. Fibrin-based hydrogels have been exploited as scaffolds for their advantages in biocompatibility, degradability and mass transportation in various

Articles

There are five identified glycosaminoglycan chains (see Figure 1): Hyaluronan is not sulfated, but the other glycosaminoglycan chains contain sulfate substituents at various positions of the chain.

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

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