A71328

4-Aminophenol

≥98%

• Synonym(s): 4-Hydroxyaniline
• Linear Formula: H₂NC₆H₄OH
• CAS Number: 123-30-8
• Molecular Weight: 109.13
• Beilstein/REAXYS Number: 385836
• EC Number: 204-616-2
• MDL number: MFCD00007869
• UNSPSC Code: 12352100
• PubChem Substance ID: 24891177
• NACRES: NA.22

Properties

• Quality Level: 200
• assay: ≥98%
• form: granular; powder or crystals
• mp: 185-189 °C (lit.)
• solubility: water: slightly soluble
• SMILES string: Nc1ccc(O)cc1
• InChI: 1S/C6H7NO/c7-5-1-3-6(8)4-2-5/h1-4,8H,7H2
• InChI key: PLIKAWJENQZMHA-UHFFFAOYSA-N

Description

General description

4-Aminophenol (4-Hydroxyaniline) is an organic building block. Its quantification in water samples upto the detection limit of 8×10^-10mol l^-1 has been proposed by employing single-wall carbon nanotubes (SWNT)-nafion film coated glassy carbon electrodes. It is present as the main contaminant in pharmaceutical formulations of paracetamol. High-performance liquid chromatographic (HPLC) method with amperometric detection has been reported for its determination in various analgesic formulations. It has been reported to be formed from the reduction of 4-nitrophenol (Nip) under metal-free conditions catalyzed by N-doped graphene (NG).

Application

4-Aminophenol is suitable for use in the synthesis of 2,2-bis(4-aminophenoxy) benzonitrile [4-APBN], a monomer required for the preparation of series of polyamides and poly(amide-imide)s. It may be used as derivatization reagent to improve the ionization of aliphatic and aromatic aldehydes by paper spray ionization mass spectrometry.

Safety Information

• pictograms: GHS08,GHS07,GHS09
• signalword: Warning
• hcodes: H302 + H332,H317,H341,H373,H410
• pcodes: P273 - P280 - P301 + P312 - P302 + P352 - P304 + P340 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 2 - Skin Sens. 1 - STOT RE 2
• target_organs: Kidney
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves