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A78403

Sigma-Aldrich

4-Aminopyridine

98%

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Synonym(s):
4-Pyridinamine, 4-Pyridylamine, 4AP, Fampridine
Empirical Formula (Hill Notation):
C5H6N2
CAS Number:
Molecular Weight:
94.11
Beilstein/REAXYS Number:
105782
EC Number:
MDL number:
PubChem Substance ID:

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1 of 4

This Item
275875A77997736023
4-Aminopyridine 98%

A78403

4-Aminopyridine

4-Aminopyridine ≥99%

275875

4-Aminopyridine

2-Aminopyridine 99%

A77997

2-Aminopyridine

3-Amino-4-iodopyridine 97%

736023

3-Amino-4-iodopyridine

Quality Level

200

Quality Level

-

Quality Level

100

Quality Level

-

solubility

H2O: 50 mg/mL, clear, colorless

solubility

DMF: soluble(lit.), DMSO: soluble(lit.), THF: soluble(lit.), acetone: soluble(lit.), acetonitrile: soluble(lit.), ethanol: soluble(lit.), isopropanol: soluble(lit.), methanol: soluble(lit.), water: soluble(lit.)

solubility

-

solubility

-

mp

155-158 °C (lit.)

mp

155-158 °C (lit.)

mp

54-58 °C (lit.)

mp

65-70 °C

bp

273 °C (lit.)

bp

273 °C (lit.)

bp

204-210 °C (lit.)

bp

-

form

crystals

form

solid

form

crystals

form

solid

General description

4-aminopyridine is a ligand and an ion channel modulator used as an acetylcholine release enhancing agent.

Application

4-Aminopyridine (4-AP) can be used as a:
  • Catalyst in the regioselective acylation of N-tosylhydrazide.
  • Starting material in the synthesis of 4-aminopyridine derivatives for neurological disorder studies.
  • Precursor for the synthesis of enantiomerically pure 4-(pyrrolidino)pyridine (PPY) derivatives by cyclocondensation reaction.

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B

Storage Class

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

312.8 °F

flash_point_c

156 °C

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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Customers Also Viewed

Slide 1 of 5

1 of 5

4-Aminopyridine catalyzed direct and regioselective acylation of N-tosylhydrazide
Namba K, et al.
Organic Letters, 11(21), 4970-4973 (2009)
Synthesis of C 2-symmetric analogues of 4-(pyrrolidino) pyridine: new chiral nucleophilic catalysts
Spivey AC, et al.
Journal of the Chemical Society, Part 1, 1(20), 3460-3468 (2000)
Development of novel 4-aminopyridine derivatives as potential treatments for neurological injury and disease
Smith DT, et al.
European Journal of Medicinal Chemistry, 40(9), 908-917 (2005)
Effect of protonated aminopyridines on the structural divergences of M (II)--malonate complexes (M= Cu, Ni, Co)
Amrita D et al.
Polyhedron, 29, 1317-1325 (2010)
4-Aminopyridine derivatives with antiamnesic activity
Aldo A et al.
European Journal of Medicinal Chemistry, 35, 77-82 (2000)

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