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E33505

Sigma-Aldrich

Ethyl isonipecotate

98%

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Synonym(s):
Ethyl 4-piperidinecarboxylate, Piperidin-4-carboxylic acid ethyl ester
Empirical Formula (Hill Notation):
C8H15NO2
CAS Number:
Molecular Weight:
157.21
Beilstein/REAXYS Number:
118419
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

98%

form

liquid

refractive index

n20/D 1.459 (lit.)

bp

204 °C (lit.)

density

1.02 g/mL at 25 °C (lit.)

SMILES string

CCOC(=O)C1CCNCC1

InChI

1S/C8H15NO2/c1-2-11-8(10)7-3-5-9-6-4-7/h7,9H,2-6H2,1H3

InChI key

RUJPPJYDHHAEEK-UHFFFAOYSA-N

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This Item
665150
Ethyl isonipecotate 98%

E33505

Ethyl isonipecotate

bp

204 °C (lit.)

bp

120-135 °C/0.5 mmHg

refractive index

n20/D 1.459 (lit.)

refractive index

n20/D 1.458

density

1.02 g/mL at 25 °C (lit.)

density

1.046 g/mL at 25 °C

form

liquid

form

-

Application

Reactant for synthesis of:
  • SMN protein modulators
  • β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition
  • Nitroethylenediamines by nucleophilic ring opening of nitroimidazolidinone
  • RhoA inhibitors for cardiovascular disease therapy
  • Saccharin derived Mannich bases as antimicrobials and antioxidants

Reactant for one-pot reductive amination and Suzuki-Miyaura cross coupling of formyl aryl and heteroaryl MIDA boronates

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

176.0 °F - closed cup

flash_point_c

80 °C - closed cup

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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