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P30004

Sigma-Aldrich

1-Phenylpiperazine

≥97.0%

Synonym(s):

N-Phenyldiethylenediamine

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About This Item

Empirical Formula (Hill Notation):
C10H14N2
CAS Number:
92-54-6
Molecular Weight:
162.23
Beilstein/REAXYS Number:
132157
EC Number:
202-165-6
MDL number:
MFCD00005957
UNSPSC Code:
12352100
PubChem Substance ID:
24898377
NACRES:
NA.22

assay

≥97.0%

refractive index

n20/D 1.588 (lit.)

bp

286 °C (lit.)

density

1.062 g/mL at 25 °C (lit.)

SMILES string

C1CN(CCN1)c2ccccc2

InChI

1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2

InChI key

YZTJYBJCZXZGCT-UHFFFAOYSA-N

Gene Information

mouse ... Htr3a(15561)
rat ... Drd2(24318) , Htr1a(24473)

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pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 3 Oral - Eye Dam. 1 - Skin Corr. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

284.0 °F

flash_point_c

140 °C

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Certificates of Analysis (COA)

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Romano Di Fabio et al.
Journal of medicinal chemistry, 52(10), 3238-3247 (2009-04-25)
In an effort to discover novel druglike NK(1) receptor antagonists a new series of suitably substituted C-phenylpiperazine derivatives was identified by an appropriate chemical exploration of related N-phenylpiperazine analogues, with the specific aim to maximize their in vitro affinity and
Rodolfo do Couto Maia et al.
Expert opinion on therapeutic patents, 22(10), 1169-1178 (2012-09-11)
The N-phenylpiperazine subunit represents one of the most versatile scaffolds used in the medicinal chemistry field. Recently, some N-phenylpiperazine derivatives have reached late stage clinical trials for the treatment of CNS disorders, thus, this is clearly a molecular template that
Daniela Poli et al.
Journal of medicinal chemistry, 54(7), 2102-2113 (2011-03-16)
Following a molecular simplification approach, we have identified the 2-phenylphthalazin-1(2H)-one (PHTZ) ring system as a new decorable core skeleton for the design of novel hA(3) adenosine receptor (AR) antagonists. Interest for this new series was driven by the structural similarity
Gilda Neves et al.
Pharmacology, biochemistry, and behavior, 89(1), 23-30 (2007-12-18)
Previous studies have demonstrated that LASSBio-579 and LASSBio-581, two N-phenylpiperazine derivatives designed for the treatment of schizophrenia, are presynaptic dopamine D(2) receptor agonists that induce a hypothermic effect in mice that is not mediated by dopamine receptor activation. The aim
Jadwiga Handzlik et al.
Bioorganic & medicinal chemistry, 20(7), 2290-2303 (2012-03-03)
An association between α(1)-adrenoceptor affinities, hERG K(+)-antagonistic properties and antiarrhythmic activities for a series of phenylpiperazine derivatives of hydantoin (2a-21a) was investigated. New compounds were synthesized and tested for their affinity for α(1)-adrenoceptors in radioligand binding assay using [(3)H]-prazosin as
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