Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

142360

Sigma-Aldrich

4-Benzylpiperidine

99%

Synonym(s):

Phenyl(4-piperidyl)methane

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C12H17N
CAS Number:
31252-42-3
Molecular Weight:
175.27
Beilstein/REAXYS Number:
132339
EC Number:
250-535-0
MDL number:
MFCD00006006
UNSPSC Code:
12352100
PubChem Substance ID:
24848521
NACRES:
NA.22

assay

99%

refractive index

n20/D 1.537 (lit.)

bp

279 °C (lit.)

mp

6-7 °C (lit.)

density

0.997 g/mL at 25 °C (lit.)

functional group

phenyl

SMILES string

C1CC(CCN1)Cc2ccccc2

InChI

1S/C12H17N/c1-2-4-11(5-3-1)10-12-6-8-13-9-7-12/h1-5,12-13H,6-10H2

InChI key

ABGXADJDTPFFSZ-UHFFFAOYSA-N

Gene Information

rat ... Htr2a(29595) , Htr2c(25187)

Looking for similar products? Visit Product Comparison Guide

General description

4-Benzylpiperidine is dopamine-selective releaser. It is a potential candidate for treatments for cocaine dependence.

Application

4-Benzylpiperidine was used to study the metabolism of 1,3-butadiene and its oxidized metabolites in perfused livers of male B6C3F1 mice and Sprague-Dawley rats.
Reactant for synthesis of:
  • Antiproliferatives
  • GABA uptake inhibitors
  • Pyridines
  • Histamine H3 antagonists
  • Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer′s and neuronal vascular diseases
  • Antiserotoninergic, antiplatelet, hemorheologic, antiarrythmic and antioxidant molecules via nucleophilic substitution

Biochem/physiol Actions

4-Benzylpiperidine inhibits the activity of rat brain monoamine oxidase-A and -B.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

233.6 °F - closed cup

flash_point_c

112 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
12903TH
S43132
14111HH
05316CH
08921CH

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Y Arai et al.
Neuroscience letters, 70(2), 255-260 (1986-10-08)
Inhibitory effects of some MPTP and MPP+ analogues on rat brain MAO activity were studied to further clarify the structure-activity relationships of MPTP neurotoxicity. Of the analogues tested, 4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine (CPTP), 4-(4-chlorobenzyl)-pyridine (CBP), 4-benzylpyridine (BPY) and 4-benzylpiperidine (BPIP) dose-dependently inhibited both
Johannes G Filser et al.
Toxicological sciences : an official journal of the Society of Toxicology, 114(1), 25-37 (2009-12-17)
The industrial chemical 1,3-butadiene (BD) is a potent carcinogen in mice and a weak one in rats. This difference is generally related to species-specific burdens by the metabolites 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane (DEB), and 3,4-epoxy-1,2-butanediol (EBD), which are all formed in
Sindhu S Ganti et al.
International journal of pharmaceutics, 550(1-2), 71-78 (2018-08-21)
The objective of our study was to develop a transdermal patch of 4-benzylpiperidine and to evaluate its in vitro transdermal permeation profile. Appropriate pressure sensitive adhesives and additives were selected based on solubility and slide crystallization studies. Release liners and
S S Negus et al.
The Journal of pharmacology and experimental therapeutics, 329(1), 272-281 (2009-01-20)
Monoamine releasers constitute one class of drugs currently under investigation as potential agonist medications for the treatment of cocaine dependence. The efficacy and safety of monoamine releasers as candidate medications may be influenced in part by their relative potency to

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service