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P50900

Sigma-Aldrich

Propargylamine

98%

Synonym(s):

2-Propynylamine, 3-Amino-1-propyne

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About This Item

Linear Formula:
HC≡CCH2NH2
CAS Number:
2450-71-7
Molecular Weight:
55.08
Beilstein/REAXYS Number:
773681
EC Number:
219-513-8
MDL number:
MFCD00008198
UNSPSC Code:
12352100
PubChem Substance ID:
24898592
NACRES:
NA.22

Quality Level

200

assay

98%

contains

≤2.5% water

refractive index

n20/D 1.449 (lit.)

bp

83 °C (lit.)

density

0.86 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

NCC#C

InChI

1S/C3H5N/c1-2-3-4/h1H,3-4H2

InChI key

JKANAVGODYYCQF-UHFFFAOYSA-N

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Application

Synthesis of a chiral, fluorescent macrocycle by 1,3-dipolar cycloaddition of propargyl amides of carbohydrate-linked amino acids and 9,10-bis(azidomethyl)anthracene.

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Description
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Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

42.8 °F - closed cup

flash_point_c

6 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
SHBR3389
SHBQ4524
SHBR1751
SHBQ0818
SHBQ0817

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The anti-Parkinsonian, irreversible, selective monoamine oxidase (MAO)-B inhibitors, selegiline (deprenyl, (R)-N-methyl-N-(1-phenylpropan-2-yl) prop-2-yn-1-amine) and rasagiline (Azilect, N-propargyl-1(R)-aminoindan), have been proven to possess neuroprotective/neurorestorative activities in cell cultures and animal models of neurodegenerative diseases. Structure-activity studies provide evidence that neuroprotection is associated
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Propargylamines can be obtained from secondary amines and terminal alkynes in chlorinated solvents by a three- and two-component synthesis catalyzed by gold compounds and nanoparticles (Au-NP) under mild conditions. The use of dichloromethane allows for the activation of two C-Cl
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