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Sigma-Aldrich

SPDP-dPEG®36-NHS ester

>95% (HPLC)

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Synonym(s):
OPSS-PEG1500-NHS ester, OPSS-PEG36-NHS ester, SPDP-PEG-NHS ester, SPDP-PEG36-NHS ester
Empirical Formula (Hill Notation):
C87H161N3O41S2
Molecular Weight:
1969.33
MDL number:

assay

>95% (HPLC)

form

solid or viscous liquid

reaction suitability

reaction type: Pegylations

polymer architecture

shape: linear
functionality: heterobifunctional

shipped in

ambient

storage temp.

−20°C

Features and Benefits

SPDP-dPEG36-NHS ester is an amphiphilic, water-soluble PEGylation reagent that is designed to crosslink amines and free thiols. SPDP (also referred to as orthopyridyl disulfide, or OPSS) reacts with sulfhydryl groups to form disulfide bonds. The N-hydroxysuccinimidyl (NHS) ester reacts with free amines to form amide bonds. The single molecular weight, discrete chain length polyethylene glycol (dPEG) chain is 115 atoms (137.8 Å) long. SPDP-dPEG36-NHS ester is used like SPDP and its related hydrophobic products. However, the water-soluble dPEG product prevents hydrophobicity-triggered precipitation of compounds to which it is conjugated. SPDP-dPEG36-NHS ester is a monodisperse equivalent of the polymeric PEG1500.

Legal Information

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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