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860524P

Avanti

C24 Ceramide (d18:1/24:0)

Avanti Polar Lipids

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Synonym(s):
N-lignoceroyl-D-erythro-sphingosine
Empirical Formula (Hill Notation):
C42H83NO3
CAS Number:
Molecular Weight:
650.11
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 10 mg (860524P-10mg)
pkg of 1 × 5 mg (860524P-5mg)
pkg of 1 × 50 mg (860524P-50mg)

manufacturer/tradename

Avanti Polar Lipids

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

OC[C@]([H])(NC(CCCCCCCCCCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC

InChI

1S/C42H83NO3/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-42(46)43-40(39-44)41(45)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2/h35,37,40-41,44-45H,3-34,36,38-39H2,1-2H3,(H,43,46)/b37-35+/t40-,41+/m0/s1

InChI key

ZJVVOYPTFQEGPH-AUTSUKAISA-N

General description

C24 Ceramide has long acyl chain length of 24 carbon units.

Application

C24 Ceramide (d18:1/24:0) has been used:
  • in the generation of small unilamellar vesicles
  • as an internal standard in liquid chromatography-mass spectrometry for ceramide quantification from rat samples
  • to test its effect on mitochondrial stress response in worms

Biochem/physiol Actions

C24 ceramide induces mitochondrial stress response. Its levels are depleted in coronary artery disease (CAD). However, elevated ceramide levels is observed in Alzheimer′s disease. C24 is synthesized during stress. It mediates spontaneous neutrophil death.

Packaging

5 mL Amber Glass Screw Cap Vial (860524P-10mg)
5 mL Amber Glass Screw Cap Vial (860524P-50mg)
5 mL Amber Glass Screw Cap Vial (860524P-5mg)

Storage Class

11 - Combustible Solids


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Ceramides and sphingomyelinases in senile plaques
Panchal M, et al.
Neurobiology of Disease, 65, 193-201 (2014)
Permeability and microstructure of model stratum corneum lipid membranes containing ceramides with long (C16) and very long (C24) acyl chains
Pullmannova P, et al.
Biophysical Chemistry, 224, 20-31 (2017)
Liposome Preparation for the Analysis of Lipid-Receptor Interaction and Efferocytosis
Voss OH, et al.
Current Protocols in Immunology, 120(1), 14-44 (2018)
Development and validation of a high-throughput LC-MS/MS assay for routine measurement of molecular ceramides
Kauhanen D, et al.
Analytical and Bioanalytical Chemistry, 408(13), 3475-3483 (2016)
Grégory Seumois et al.
Journal of leukocyte biology, 81(6), 1477-1486 (2007-03-03)
Neutrophils rapidly undergo spontaneous apoptosis following their release from the bone marrow. Although central to leukocyte homeostasis, the mechanisms that regulate neutrophil apoptosis remain poorly understood. We show here that apoptosis of cultured neutrophils is preceded by a substantial increase

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