A-084

Androstene-3,17-dione-2,3,4-¹³C₃ solution

100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

• Synonym(s): Androstene-3,17-dione-2,3,4-¹³C₃ solution
• Empirical Formula (Hill Notation): ¹³C₃C₁₆H₂₆O₂
• CAS Number: 327048-86-2
• Molecular Weight: 289.39
• EC Number: 200-835-2
• MDL number: MFCD17677359
• UNSPSC Code: 41116107
• PubChem Substance ID: 329770636
• NACRES: NA.24

Properties

• grade: certified reference material
• form: liquid
• feature: SNAP-N-SPIKE^®, SNAP-N-SHOOT^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 100 μg/mL in acetonitrile
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: −20°C
• SMILES string: C[C@]12CC[C@H]3[C@@H](CCC4=[13CH][13C](=O)[13CH2]C[C@]34C)[C@@H]1CCC2=O
• InChI: 1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1/i7+1,11+1,13+1
• InChI key: AEMFNILZOJDQLW-FZIFMXJCSA-N

Description

General description

Androstenedione is a hormone and intermediate in the biochemical pathway for producing testosterone, estrone, and estradiol. This stable labeled internal standard is suitable for numerous LC/MS and GC/MS applications in endocrinology, clinical chemistry, neonatal screening, sports testing, and isotope dilution methods.

Application

• Stable Isotope-Labeled Steroids: Research in "Biotechnol J" explores the production and purity of 9-OH-AD from phytosterols by balancing metabolic flux, utilizing stable isotope-labeled intermediates like Androstene-3,17-dione-¹³C₃ to elucidate the pathways involved in steroid metabolism (Zhu et al., 2024).


• Steroid Metabolism Studies: The work published in "Methods Mol Biol" details the scale-up of phytosterols bioconversion into Androstenedione, demonstrating the practical applications of carbon-13 enriched androstenedione in enhancing biochemical production processes and pharmaceutical research (Martínez-Cámara et al., 2023).


• Mass Spectrometry Standards: Another study in "Methods Mol Biol" discusses the biocatalysis of steroids in both aqueous and organic media, highlighting the use of carbon-13 tracers like Androstene-3,17-dione-¹³C₃ to track enzymatic reactions and optimize conditions for industrial applications (de Carvalho CCCR and Fernandes, 2023).


• Analytical Reference Material: Further use of Androstene-3,17-dione-¹³C₃ is reported in the small-scale bioconversion of β-Sitosterol, where microtiter plates and microfluidic reactors are employed to study steroid transformations, thus providing crucial insights for pharmaceutical and biochemical research (Marques et al., 2023).


• Pharmaceutical Research Chemicals: The identification and characterization of bile acid aerobic catabolic pathways using Pseudomonas highlight the utility of carbon-13 labeled compounds like Androstene-3,17-dione-¹³C₃ in understanding complex metabolic networks, aiding in the development of therapeutic agents (Luengo et al., 2023).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS02,GHS07
• signalword: Danger
• hcodes: H225,H302 + H312 + H332,H319
• pcodes: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 2
• flash_point_f: 35.6 °F - closed cup
• flash_point_c: 2 °C - closed cup