D-915
Desalkylflurazepam solution
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Recommended Products
grade
certified reference material
Quality Level
form
liquid
feature
Snap-N-Spike®/Snap-N-Shoot®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
drug control
Narcotic Licence Schedule B (Switzerland)
concentration
1.0 mg/mL in methanol
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
storage temp.
−20°C
SMILES string
Fc1ccccc1C2=NCC(=O)Nc3ccc(Cl)cc23
InChI
1S/C15H10ClFN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)
InChI key
UVCOILFBWYKHHB-UHFFFAOYSA-N
General description
Desalkylflurazepam, also known as N-desalkyl-2-oxoquazepam, is a long-acting metabolite of the benzodiazepine drug flurazepam. Flurazepam is sold unde the trade names Dalmane and Dalmadorm for the treatment of mild to moderate insomnia. This Certified Spiking Solution® is suited for use in LC/MS or GC/MS applications for clinical toxicology, forensic analysis or urine drug testing.
Application
- Pharmacokinetic profiling: Research on flurazepam metabolites, including Desalkylflurazepam, utilizes high-performance liquid chromatography for detailed pharmacokinetic studies in rats, providing essential data for understanding drug behavior and metabolism (Lau et al., 1987).
- Neuroscience tool: Desalkylflurazepam is applied in neuroscience research to understand the dynamics of benzodiazepine binding on living cells, utilizing small ligands in fluorescence correlation spectroscopy, a method pivotal for real-time molecular interactions study (Hegener et al., 2002).
- Drug testing applications: The compound is used in the development of analytical techniques like ultra-high-performance liquid chromatography-mass spectrometry (UHPLC-MS/MS) for the detection of benzodiazepines in hair, useful in workplace drug testing and forensic science (Ramírez Fernández et al., 2015).
- Toxicological analysis: Desalkylflurazepam serves as a reference standard in forensic toxicology to facilitate the rapid determination of benzodiazepines and their metabolites in biological samples, crucial for accurate and swift diagnostic purposes (Jeong et al., 2015).
- Immunosorbent assay applications: This benzodiazepine metabolite is instrumental in examining cross-reactivity of psychoactive substances in enzyme-linked immunosorbent assay (ELISA) techniques, enhancing drug testing capabilities in clinical settings (Cieri et al., 2024).
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
related product
Product No.
Description
Pricing
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes,Central nervous system
Storage Class
3 - Flammable liquids
wgk_germany
WGK 2
flash_point_f
49.5 °F - closed cup
flash_point_c
9.7 °C - closed cup
Certificates of Analysis (COA)
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S Ueki et al.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 82(5), 395-409 (1983-11-01)
The behavioral effects of ethyl loflazepate and its metabolites were investigated in mice and rats, and they were compared with those of diazepam, nitrazepam and lorazepam. Locomotor activity of rats in open-field situation was increased with a wide range of
M Chung et al.
Clinical pharmacology and therapeutics, 35(4), 520-524 (1984-04-01)
Quazepam, a benzodiazepine hypnotic, was studied in normal subjects to evaluate steady-state kinetics of quazepam and of its major active plasma metabolites, 2-oxoquazepam and N-desalkyl-2-oxoquazepam, after 15 mg once daily by mouth for 14 days. The kinetics of quazepam and
J Hilbert et al.
Drug metabolism and disposition: the biological fate of chemicals, 12(4), 452-459 (1984-07-01)
The disposition of 14C-quazepam (7-chloro-(2,2,2-trifluoroethyl) [5-14C]-5-o-fluorophenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-thione), a new benzodiazepine hypnotic, was studied in hamsters and mice after iv and po dosing. In both species, quazepam was rapidly absorbed, as indicated by the plasma Cmax being reached within 1 hr of
Y Sakai et al.
Japanese journal of pharmacology, 37(4), 373-379 (1985-04-01)
A new benzodiazepine compound, ethyl loflazepate (ethyl-7-chloro-2,3-dihydro-5-(2-fluorophenyl)-2-oxo-1H,1,4- benzodiazepine-3-carboxylate; CM6912) was studied using in vitro experimental systems for its displacement activity on 3H-diazepam binding to the synaptosomal membrane fraction of rat cerebrum and potentiating action on GABA. CM6912 inhibited the specific
S K Gupta et al.
Pharmaceutical research, 5(6), 365-368 (1988-06-01)
A reverse-phase liquid chromatographic method is described for simultaneous quantification of quazepam, and two of its metabolites, 2-oxoquazepam and N-desaklyl-2-oxoquazepam. The method uses a solid-phase extraction procedure to prepare plasma samples. After extraction, the methanolic extract is evaporated; the residue
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