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M-096

Supelco

Morphine-6-β-D-glucuronide solution

100 μg/mL in methanol: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®

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Empirical Formula (Hill Notation):
C23H27NO9
CAS Number:
Molecular Weight:
461.46
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentration

100 μg/mL in methanol: water (1:1)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

CN1CC[C@]23[C@H]4Oc5c(O)ccc(C[C@@H]1[C@@H]2C=C[C@@H]4O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)c35

InChI

1S/C23H27NO9/c1-24-7-6-23-10-3-5-13(31-22-17(28)15(26)16(27)19(33-22)21(29)30)20(23)32-18-12(25)4-2-9(14(18)23)8-11(10)24/h2-5,10-11,13,15-17,19-20,22,25-28H,6-8H2,1H3,(H,29,30)/t10-,11+,13-,15-,16-,17+,19-,20-,22+,23-/m0/s1

InChI key

GNJCUHZOSOYIEC-GAROZEBRSA-N

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General description

Morphine-6-β-D-glucuronide is a primary plasma and urinary metabolite of the opiate analgesic morphine. Sold under trade names including MS Contin®, Kadian®, Oramorph®, and Roxanol for pain relief, morphine is also a commonly abused recreational drug. This certified analytical reference standard is suitable for a variety of GC/MS or LC/MS applications from pain prescription monitoring and urine drug testing to clinical toxicology and forensic analysis.

Application

  • Pharmacokinetics and Clinical Study Applications: A method involving liquid chromatography coupled to tandem mass spectrometry was developed and validated for the simultaneous quantification of several analgesics, including Morphine-6-β-D-glucuronide, applied in a clinical study for determining neurological death in intensive care units (Jutras et al., 2020).
  • Opioid Receptor Research: Research highlighted the higher efficacy of Morphine-6-β-D-glucuronide compared to morphine as a mu-opioid receptor agonist in the rat locus coeruleus, supporting its use in detailed opioid receptor studies (Osborne et al., 2000).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Kadian is a registered trademark of Actavis Elizabeth LLC
MS Contin is a registered trademark of Purdue Frederick Company
Oramorph is a registered trademark of AAIPharma, Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 3 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

75.2 °F - closed cup

flash_point_c

24 °C - closed cup


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