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O-902

Supelco

Oxazepam solution

1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C15H11ClN2O2
CAS Number:
604-75-1
Molecular Weight:
286.71
EC Number:
200-659-6
MDL number:
MFCD00057903
UNSPSC Code:
41116107
PubChem Substance ID:
329818934
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

concentration

1 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

OC1N=C(c2ccccc2)c3cc(Cl)ccc3NC1=O

InChI

1S/C15H11ClN2O2/c16-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)18-15(20)14(19)17-12/h1-8,15,20H,(H,17,19)

InChI key

ADIMAYPTOBDMTL-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

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General description

A Certified Spiking Solution® used as a starting material in calibrators and controls for GC/MS or LC/MS testing applications in pain prescription monitoring, clinical toxicology, or forensic analysis. Oxazepam is a benzodiazepine drug used to treat anxiety and insomnia and to control the symptoms of alcohol withdrawal.

Application


  • Oxazepam research solution: Oxazepam is widely used in pharmaceutical research to study its effects and metabolic pathways in the body. Advanced LC-MS/MS methods have been developed to determine oxazepam in biological samples, providing precise data on its pharmacokinetics and pharmacodynamics (Matsuo et al., 2024).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany

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O-023

Oxazepam glucuronide solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

O-901

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O-904

Oxazepam-d5 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

O-057

Oxazepam glucuronide lithium salt solution, 100 μg/mL in methanol ((as free carboxylate)), certified reference material, ampule of 1 mL, Cerilliant®

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Joel Hellrup et al.
International journal of pharmaceutics, 409(1-2), 96-103 (2011-03-02)
The aim of this study was to explore how pharmaceutical micro-sized filler particles affect the amorphous stability of sucrose in sucrose/filler particle composites produced by freeze-drying. Focus was put on the filler particles' properties crystallinity, hygroscopicity, hydrophobicity, and surface area
T Brodin et al.
Science (New York, N.Y.), 339(6121), 814-815 (2013-02-16)
Environmental pollution by pharmaceuticals is increasingly recognized as a major threat to aquatic ecosystems worldwide. A variety of pharmaceuticals enter waterways by way of treated wastewater effluents and remain biochemically active in aquatic systems. Several ecotoxicological studies have been done
M H Lader
Acta psychiatrica Scandinavica. Supplementum, (274)(274), 89-93 (1978-01-01)
The benzodiazepines have been available now for about 15 years but new aspects of their actions are being elucidated all the time. Oxazepam has a short half-life and inactive metabolites and therefore differs from most other benzodiazepines. Some aspects of
Katarina Gospic et al.
PLoS biology, 9(5), e1001054-e1001054 (2011-05-12)
Imaging studies have revealed a putative neural account of emotional bias in decision making. However, it has been difficult in previous studies to identify the causal role of the different sub-regions involved in decision making. The Ultimatum Game (UG) is
Pharmacokinetics in clinical medicine: oxazepam versus other benzodiazepines.
D J Greenblatt et al.
Diseases of the nervous system, 36(5 Pt. 2), 6-13 (1975-05-01)
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Protocols

LC/MS (TOF) Analysis of Drugs and Their Glucuronide Metabolites in Urine on Titan™ C18 After Solid Phase Extraction (SPE) Using Supel™-Select SCX, β-Glucuronidase Enzyme Digestion

-THC solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material

UHPLC/MS for Drug Detection in Urine

Optimize β-glucuronidase hydrolysis for glucuronide metabolite analysis considering factors like time, temperature, pH, and enzyme concentration.

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