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V-042

Supelco

Vitamin K2 (MK-4)-13C6 solution

10 μg/mL in acetonitrile, certified reference material, ampule of 1 mL, Cerilliant®

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Synonym(s):
13C6-Labeled Vitamin K2 (MK-4)
Empirical Formula (Hill Notation):
C2513C6H40O2
Molecular Weight:
30327.27
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

10 μg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−70°C

General description

This stable-labeled internal standard is suitable for quantification of vitamin K2 (MK-4) in LC-MS/MS clinical testing applications such as assessment of vitamin K2 deficiency and research of VKD proteins. Vitamin K2 (MK-4) or menaquinone-4 is an essential cofactor for enzymes that activate blood-clotting factors as well as vitamin K-dependent (VKD) proteins involved in bone metabolism, arterial calcification, growth control, and signal transduction.

Application


  • Menaquinone-4 prevents medication-related osteonecrosis of the jaw: Utilizing Vitamin K2 (MK-4)-¹³C₆, this research highlights its potential in preventing osteonecrosis via SIRT1 signaling, crucial for reducing osteoblast apoptosis under metabolic stresses, beneficial for pharmaceutical studies related to bone health and safety (Cui et al., 2023).

  • Reference Range of Vitamin K Evaluating Indicators in Chinese Childbearing Women: This study uses ¹³C₆-labeled Vitamin K2 (MK-4) to establish reference ranges for vitamin K, critical for understanding its bioavailability in populations at risk of deficiency, aiding in nutritional assessments and supplement development (Nie et al., 2023).

  • Development of a liquid chromatography mass spectrometry method for the determination of vitamin K1, menaquinone-4: The application of Vitamin K2 (MK-4)-¹³C₆ in LC-MS methods enhances the accuracy of measuring vitamin K levels in serum without supplementation, providing vital data for clinical diagnostics and nutritional research (Meinitzer et al., 2022).

  • Vitamin K (phylloquinone and menaquinones) in foods: Research uses Vitamin K2 MK-4-¹³C₆ for cost-effective quantification in foods via LC-ESI-MS/MS, supporting efforts in food science to accurately report vitamin K content, which is essential for consumer health and regulatory compliance (Jensen et al., 2022).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

FlameExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

wgk_germany

WGK 2

flash_point_f

35.6 °F

flash_point_c

2.0 °C


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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