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07-1491

Sigma-Aldrich

Anti-Calcineurin pan A Antibody

from rabbit, purified by affinity chromatography

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Synonym(s):
CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit alpha isoform, calcineurin A alpha, protein phosphatase 3 (formerly 2B), catalytic subunit,

alpha isoform, protein phosphatase 3 (formerly 2B), catalytic subunit,

alp
eCl@ss:
32160702

biological source

rabbit

Quality Level

100
200

conjugate

conjugate

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

liquid

purified by

affinity chromatography

species reactivity

human, rat, mouse

species reactivity (predicted by homology)

mammals (based on 100% sequence homology)

technique(s)

western blot: suitable

immunogen sequence

KLH-conjugated synthetic peptide corresponding to Calcineurin.

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

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This Item
07-149207-149307-068-I
conjugate

conjugate

conjugate

-

conjugate

-

conjugate

-

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

form

liquid

form

-

form

-

form

-

species reactivity

human, rat, mouse

species reactivity

rat, mouse, human

species reactivity

human

species reactivity

human, rat, mouse

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General description

Calcineurin is a serine/threonine protein phosphatase involved in the mediation of signal tranduction in a wide variety of cellular responses. Calcineurin has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin′s multifunctional capabilities in the regulation of calcium signaling.

Specificity

This antibody recognizes both the Aα and Aβ, the major catalytic subunit gene isoforms of calcineurin in most tissues; may also react with the testis form, Aγ. This antibody has very high sensitivity and specificity, which allow detection of calcineurin in tissues where expression is low, such as lymphoid tissue. Reacts with calcineurin of all mammalian species.

Immunogen

KLH-conjugated synthetic peptide corresponding to Calcineurin.

Application

Detect Calcineurin pan A using this Anti-Calcineurin pan A Antibody validated for use in WB.
Research Category
Signaling
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling

Quality

Evaluated by Western Blot in Mouse brain lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected Calcineurin on 10 µg of mouse brain lysate.

Target description

~58 kDa

Linkage

Replaces: AB1695

Physical form

Affinity purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 40% gylerol. Contains no preservative.

Storage and Stability

Store at -20°C for up to 12 months in undiluted aliquots; at this temperature the solution will
remain unfrozen.

Analysis Note

Control
Mouse brain lysate

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Kelly M Grimes et al.
Frontiers in physiology, 14, 1054169-1054169 (2023-02-04)
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