07-250
Anti-PP2A Antibody, A subunit
Upstate®, from rabbit
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Synonym(s):
Anti-MRD36, Anti-PP2AA, Anti-PP2AAALPHA, Anti-PR65A
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, mouse, Xenopus, pig, rat
manufacturer/tradename
Upstate®
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... PPP2R1A(5518)
Specificity
PP2A A subunit, α isoform
Immunogen
KLH-conjugated, synthetic peptide of 13 amino acids (MAAADGDDSLY-Ahx-C), containing amino acids 1-11 of human PP2A, A subunit. Ahx is aminohexanoic acid. The immunizing sequence is conserved in human, mouse, rat, porcine and Xenopus.
Application
Anti-PP2A Antibody, A subunit detects level of PP2A & has been published & validated for use in IP & WB.
Research Sub Category
Synapse & Synaptic Biology
Neurodegenerative Diseases
Synapse & Synaptic Biology
Neurodegenerative Diseases
Quality
Routinely evaluated by immunoblot on RIPA lysates from 3T3/A31 cells.
Target description
63-65kDa
Physical form
100mM triethylamine, 100mM sodium phosphate, 0.02% sodium azide before the addition of glycerol to 30%.
Analysis Note
Control
Positive Antigen Control: Catalog #12-305, 3T3/A31 lysate. Add 2.5 μL of 2-mercapto-ethanol/100 μL of lysate and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced lysate per lane for minigels.
Positive Antigen Control: Catalog #12-305, 3T3/A31 lysate. Add 2.5 μL of 2-mercapto-ethanol/100 μL of lysate and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced lysate per lane for minigels.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
wgk_germany
WGK 1
Certificates of Analysis (COA)
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Sonia Chelouah et al.
Cancers, 10(1) (2018-01-06)
The Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) acts as a co-activator of EBNA-2, a transcriptional activator essential for Epstein-Barr virus (EBV)-induced B-cell transformation. Burkitt's lymphoma (BL) cells harboring a mutant EBV strain that lacks both the EBNA-2 gene and
R Ruediger et al.
Oncogene, 20(1), 10-15 (2001-03-13)
The A subunit of protein phosphatase 2A (PP2A) consists of 15 nonidentical repeats. The catalytic C subunit binds to C-terminal repeats 11 - 15 and regulatory B subunits bind to N-terminal repeats 1 - 10. Recently, four cancer-associated mutants of
Matthew L Kutys et al.
Nature cell biology, 16(9), 909-917 (2014-08-26)
Rho-family GTPases govern distinct types of cell migration on different extracellular matrix proteins in tissue culture or three-dimensional (3D) matrices. We searched for mechanisms selectively regulating 3D cell migration in different matrix environments and discovered a form of Cdc42-RhoA crosstalk
Sorcha Finnegan et al.
The European journal of neuroscience, 32(3), 322-334 (2010-07-20)
Cell survival signalling involving the PI3K/Akt survival pathway can be negatively regulated by several phosphatases including PP2A. When retinal-derived 661W cells were subjected to trophic factor deprivation this initiated a survival response through inhibition of the activity of PP2A and
G A Calin et al.
Oncogene, 19(9), 1191-1195 (2000-03-14)
The phosphatase 2A (PP2A) is one of the major cellular serine-threonine phosphatases. It was recently shown that the gene encoding for the beta isoform of its subunit A, PPP2R1B, is altered in human lung and colorectal carcinomas, suggesting a role
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