MilliporeSigma

1.00247

SAFC

Citric acid

anhydrous fine-granular, EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, JP, USP, FCC, E 330

Synonym(s):
2-Hydroxypropane-1,2,3-tricarboxylic acid, Hydroxytricarballylic acid
Linear Formula:
HOC(COOH)(CH2COOH)2
CAS Number:
Molecular Weight:
192.12
Beilstein:
782061
MDL number:
E Number:
E330
EC Index Number:
201-069-1

Agency

BP
ChP
JP
Ph. Eur.
USP

Quality Level

reg. compliance

FCC

vapor pressure

<0.1 hPa ( 20 °C)

product line

EMPROVE® ESSENTIAL

Assay

99.5-100.5% substance (anhydrous) basis (alkalimetric)

form

coarse powder

potency

3000 mg/kg LD50, oral (Rat)

expl. lim.

8 %, 65 °F

pH

1.7 (20 °C, 100 g/L in H2O)

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

bp

200 °C/1013 hPa (decomposition)

mp

153-159 °C (lit.)

solubility

water: 1330 g/L at 20 °C

density

1.665 g/cm3 at 18 °C

cation traces

Al: ≤0.2 ppm
As: ≤1 ppm
Hg: ≤1 ppm
Pb: ≤0.5 ppm
heavy metals (as Pb): ≤5 ppm

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

2-30°C

SMILES string

OC(=O)CC(O)(CC(O)=O)C(O)=O

InChI

1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChI key

KRKNYBCHXYNGOX-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
1.370021.002411.00242
Citric acid anhydrous fine-granular, EMPROVE&#174; ESSENTIAL, Ph. Eur., BP, ChP, JP, USP, FCC, E 330

SAFC

1.00247

Citric acid

Citric acid anhydrous powder, EMPROVE&#174; EXPERT, Ph. Eur., BP, ChP, JP, USP

SAFC

1.37002

Citric acid

Citric acid anhydrous powder, EMPROVE&#174; ESSENTIAL, Ph. Eur., BP, JP, USP, FCC, E 330

SAFC

1.00241

Citric acid

Citric acid monohydrate crystalline, EMPROVE&#174; ESSENTIAL, Ph. Eur., BP, ChP, USP, FCC, E 330

SAFC

1.00242

Citric acid monohydrate

vapor pressure

<0.1 hPa ( 20 °C)

vapor pressure

<0.1 hPa ( 20 °C)

vapor pressure

<0.1 hPa ( 20 °C)

vapor pressure

<1 Pa ( 25 °C)

assay

99.5-100.5% substance (anhydrous) basis (alkalimetric)

assay

99.5-100.5% substance (anhydrous) basis (alkalimetric)

assay

99.5-100.5% substance (anhydrous) basis (alkalimetric)

assay

-

form

coarse powder

form

fine powder, solid

form

fine powder

form

coarse powder, crystalline

pH

1.7 (20 °C, 100 g/L in H2O)

pH

1.7 (20 °C, 100 g/L in H2O)

pH

1.7 (20 °C, 100 g/L in H2O)

pH

1.85 (25 °C, 50 g/L in H2O)

bp

200 °C/1013 hPa (decomposition)

bp

200 °C/1013 hPa (decomposition)

bp

200 °C/1013 hPa (decomposition)

bp

-

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Citric acid is typically used as pH adjuster, buffer agent or as antioxidant in pharmaceutical formulations. Its application range spans across different formulation types, including semi-solid dosage forms, liquid dosage forms such as solutions and solid dosage forms such as effervescent tablets or granules.
Citric acid anhydrous powder Emprove® Essential is citric acid present in its water-free, fine granulated form.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (Example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

Slide 1 of 9

1 of 9

Citric acid certified reference material, TraceCERT&#174;, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

94676

Citric acid

Citric Acid, Anhydrous anhydrous Meets ACS Specifications, Meets Reagent Specifications for testing USP/NF monographs GR ACS

Supelco

CX1723

Citric Acid, Anhydrous

Citric acid &#8805;99.5%, FCC, FG

Sigma-Aldrich

W230618

Citric acid

Citric acid anhydrous, European Pharmacopoeia (EP) Reference Standard

A1202000

Citric acid

Caprylic acid (Octanoic acid) EMPROVE&#174; EXPERT, Ph. Eur., NF

SAFC

1.00193

Caprylic acid (Octanoic acid)

Potassium sorbate granules, EMPROVE&#174; ESSENTIAL, Ph. Eur., BP, NF, FCC, E 202

SAFC

1.05119

Potassium sorbate

Citric acid BioUltra, anhydrous, &#8805;99.5% (T)

Sigma-Aldrich

27487

Citric acid

Saccharin sodium dihydrate EMPROVE&#174; ESSENTIAL, Ph. Eur., USP

SAFC

8.17042

Saccharin sodium dihydrate

Citric acid monohydrate powder, EMPROVE&#174; ESSENTIAL, Ph. Eur., BP, ChP, JP, USP, FCC, E 330

SAFC

1.00243

Citric acid monohydrate

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service