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MilliporeSigma

Buffer & Media Prep

Three stainless steel bioreactor vessels of varying sizes on wheeled stands, each with a blue and pink ‘M’ logo on the front.

Buffer and media preparation play a critical role in manufacturing operations affecting process efficiency, safety, and yield. Our comprehensive portfolio of high-quality cell culture media, buffers, and pH adjusters are supported by extensive, easily accessible, quality documentation packages to support risk assessments and meet your compliance needs.

Our single-use mixers are ideally suited for buffers and media prep and offer options for gentle mixing of protein and shear sensitive products as well as hard to dissolve materials and buffers. These mixers increase flexibility and production capacity by reducing start up time and minimizing process down time. 

For bioburden control, our portfolio of time tested bioburden reduction and sterilizing filters can meet the buffer and media filtration needs for every process while our virus retentive filters offer an additional level of biosafety assurance for more critical applications.

A variety of laboratory filtration devices, including several sizes of filter columns and flasks, used for buffer filtration in scientific research.

Buffer Filtration

There are multiple options for buffer filtration in biomanufacturing. Filter selection is based on process biosafety needs, buffer throughput, and economics. Filters for processing buffers in biomanufacturing provide bioburden control, sterilizing-grade, or virus retention performance.

Media Filtration

Cell culture media filtration prevents bioreactor contamination. Selection of a sterilizing filter, mycoplasma filter, or virus filter depends on process risk.  Learn how to select the best filter for your cell culture media filtration.

A blue water filtration tank and control unit with stylized representations of water molecules and filtration media particles around it, symbolizing the process of media filtration.

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Three blue containers with white labels and varying lid colors.
Buffers & pH Adjusters

Our broad portfolio of buffer materials manufactured according to GMP guidelines includes excipients specifically for drug formulation and manufacturing, including high-risk applications. Whether your product is a small or large molecule drug, we offer high-quality buffers and pH adjusters with regulatory support.

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A set of three stainless steel single-use mixers on wheels, designed for single-use mixing.
Single-use Mixers

Our complete range of Mobius® single-use mixing solutions can meet your needs for mixing pharmaceutical ingredients from intermediate to final drug products, as well as preparation of process solutions such as buffers and media. 

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