MilliporeSigma
All Photos(3)

1.08386

SAFC

Tris(hydroxymethyl)aminomethane

(Trometamol), EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, JPC, USP

Synonym(s):
Tromethamine, 2-Amino-2-(hydroxymethyl)-1,3-propanediol, THAM, Tris base, Trometamol
Linear Formula:
NH2C(CH2OH)3
CAS Number:
Molecular Weight:
121.14
Beilstein:
741883
MDL number:
EC Index Number:
201-064-4

Agency

BP
ChP
JPC
Ph. Eur.
USP

Quality Level

vapor pressure

0.0267 hPa ( 20 °C)

product line

EMPROVE® ESSENTIAL

form

solid

pH

10.2-10.6 (20 °C, 6 g/L in H2O)

useful pH range

7-9

pKa (25 °C)

8.1

bp

219-220 °C/10 mmHg (lit.)
219-220 °C/13.3 hPa

mp

167-172 °C (lit.)

solubility

678 g/L

density

1.35 g/cm3 at 23 °C

application(s)

ophthalmics
pharmaceutical

storage temp.

no temp limit

SMILES string

NC(CO)(CO)CO

InChI

1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2

InChI key

LENZDBCJOHFCAS-UHFFFAOYSA-N

Compare Similar Items

View Full Comparison

1 of 4

This Item
2528591.083821.08387
agency

BP, ChP, JPC, Ph. Eur., USP

agency

-

agency

reag. Ph. Eur.

agency

-

product line

EMPROVE® ESSENTIAL

product line

-

product line

-

product line

-

form

solid

form

crystalline

form

solid

form

solid

pH

10.2-10.6 (20 °C, 6 g/L in H2O)

pH

-

pH

10.2-10.6 (20 °C, 6 g/L in H2O)

pH

10.2-10.6 (20 °C, 6 g/L in H2O)

mp

167-172 °C (lit.)

mp

167-172 °C (lit.)

mp

167-172 °C (lit.)

mp

167-172 °C (lit.)

solubility

678 g/L

solubility

-

solubility

678 g/L

solubility

678 g/L

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Tris(hydroxymethyl)aminomethane (Trometamol) is a commonly used buffer component in biomolecule downstream chromatography steps as well as final liquid formulation.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials. Four document types are included with an Emprove® Program subscription:

Quality Management Dossier (Open Access)

Free of charge - Sign in to download

Operational Excellence Dossier

Available by subscription or for a fee

Learn more about the benefits an Emprove® Program subscription can provide
Why are these documents unavailable?
Emprove® Dossiers contain information intended to support the registration process and risk assessment activities of pharmaceutical producers and contain confidential information. Please contact us if you would like access.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

(enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service