MilliporeSigma

1.00590

SAFC

Glycine

crystalline, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

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Synonym(s):
Glycine, Gly, Aminoacetic acid, Aminoethanoic acid, Aminoacetic acid, Aminoethanoic acid, Glycocoll
Linear Formula:
NH2CH2COOH
CAS Number:
Molecular Weight:
75.07
Beilstein/REAXYS Number:
635782
MDL number:
EC Index Number:
200-272-2

agency

BP
ChP
JP
Ph. Eur.
USP

Quality Level

vapor pressure

0.0000171 Pa ( 25 °C)

description

EMPROVE® EXPERT Ph Eur,BP,JP,USP

product line

EMPROVE® EXPERT

assay

98.5-101.0% (calculated on dried substance, perchloric acid titration)

form

crystalline
solid

technique(s)

inhibition assay: suitable

pH

5.9-6.4 (20 °C, 50 g/L in H2O)

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

mp

240 °C (dec.) (lit.)

solubility

soluble 250 g/L

density

1.161 g/cm3 at 20 °C

application(s)

liquid formulation
parenterals
pharma/biopharma processes
pharmaceutical

storage temp.

2-30°C

SMILES string

NCC(O)=O

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

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1 of 4

This Item
PHR11111.03669G8898
Glycine crystalline, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

1.00590

Glycine

Glycine Pharmaceutical Secondary Standard; Certified Reference Material

PHR1111

Glycine

Glycine granulated, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

1.03669

Glycine

Glycine suitable for electrophoresis, ≥99%

G8898

Glycine

assay

98.5-101.0% (calculated on dried substance, perchloric acid titration)

assay

-

assay

99.0-101.0% (calculated on dried substance, perchloric acid titration)

assay

≥99%

form

crystalline, solid

form

-

form

granular

form

powder

technique(s)

inhibition assay: suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

inhibition assay: suitable

technique(s)

electrophoresis: suitable, western blot: suitable

mp

240 °C (dec.) (lit.)

mp

240 °C (dec.) (lit.)

mp

240 °C (dec.) (lit.)

mp

240 °C (dec.) (lit.)

solubility

soluble 250 g/L

solubility

-

solubility

-

solubility

H2O: 200 mg/mL, clear, colorless to faintly yellow

General description

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Glycine is an amino acid which is used widely in the biopharma industry as stabilizer, tonicity modifier, buffer and precipitating agent. It is also used as an emollient, emulsifying agent and solubilizer in solid and semi-solid formulations.
Due to its low microbial and endotoxin limits, Glycine cryst. Emprove® Expert is especially suitable for high-risk applications.

Biochem/physiol Actions

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

The substance 1.00590 has no REACH registration because the only supported use is the use in medicinal products for human or veterinary use or in food or feedingstuffs according to article 2 of the REACH Regulation (EC) No 1907/2006.

Application

Product No.
Description
Pricing

related product

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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