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G7126

Sigma-Aldrich

Glycine

ReagentPlus®, ≥99% (HPLC)

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Synonym(s):
Aminoacetic acid, Aminoethanoic acid, Glycocoll
Linear Formula:
NH2CH2COOH
CAS Number:
Molecular Weight:
75.07
Beilstein:
635782
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

Quality Level

product line

ReagentPlus®

Assay

≥99% (HPLC)

form

powder

technique(s)

western blot: suitable

impurities

≤0.01% Ammonia

loss

≤0.2% loss on drying

color

white to off-white

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

mp

240 °C (dec.) (lit.)

solubility

H2O: 200 mg/mL, clear, colorless to faintly yellow

cation traces

≤0.01% (Ammonia (NH3))

functional group

amine
carboxyl

storage temp.

room temp

SMILES string

NCC(O)=O

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

Gene Information

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This Item
G8898G74033570
Glycine ReagentPlus®, ≥99% (HPLC)

Sigma-Aldrich

G7126

Glycine

-
Glycine suitable for electrophoresis, ≥99%

Sigma-Aldrich

G8898

Glycine

-
Glycine BioXtra, ≥99% (titration)

Sigma-Aldrich

G7403

Glycine

Premium Grade
Glycine

Millipore

3570

Glycine

-
assay

≥99% (HPLC)

assay

≥99%

assay

≥99% (titration)

assay

>99% (by assay)

form

powder

form

powder

form

powder

form

crystalline solid

technique(s)

western blot: suitable

technique(s)

electrophoresis: suitable, western blot: suitable

technique(s)

electron microscopy: suitable

technique(s)

-

impurities

≤0.01% Ammonia

impurities

≤0.01% Insoluble matter

impurities

Insoluble matter, passes filter test

impurities

≤100 CFU/g Total microorganism, ≤6.0 EU/g Endotoxin

color

white to off-white

color

white to off-white

color

white

color

white

General description

Glycine is a non-chiral amino acid. Glycine is a molecule with pI of 6.7, which is similar to the pH of stacking region in polyacrylamide gels. It has advantage of low mobility, hydrophobicity and it does not associate with proteins.
Glycine is a proteinogenic amino acid that plays a diverse array of roles in biochemistry and physiology. This non-essential, non-polar glucogenic amino acid acts as an inhibitory neurotransmitter in the central nervous system, but also works alongside glutamate as a co-agonist at NMDA receptors. As a precursor, glycine serves as a building block for various macromolecules, playing a crucial role in cellular processes.

Beyond its vital biological functions, glycine demonstrates remarkable versatility in various research applications. Its application as a biochemical reagent makes it invaluable in numerous assays and procedures. Its buffering capacity allows it to play a critical role in protein analysis techniques like SDS-PAGE and Western Blotting, chromatography, and cell culture. Glycine′s zwitterionic nature makes it an effective buffer across a range of pH values. In immunology research, it is widely used in the preparation of buffers for Western Blotting and other techniques. Additionally, its compatibility with various enzymes makes it useful in enzymatic assays like lactate determination. Furthermore, glycine contributes to the formulation of buffers for protein stabilization, pH control, and enzymatic reactions.

Application

  • Glycine has been added in the transfer buffer during western blotting procedure.
  • It has been used in the solution prepared for dissolving formazan crystals in the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide) cytotoxicity assay.
  • It has been used for terminating the rat basophilic leukemia (RBL) assay.

Biochem/physiol Actions

Glycine is an inhibitory neurotransmitter in the central nervous system and works as an allosteric regulator of NMDA (N-methyl-D-aspartate) receptors. It is involved in processing of motor and sensory data, thereby regulating movement, vision and audition.
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Features and Benefits

  • Suitable for Cell Biology and Biochemical research
  • High-quality compound suitable for multiple research applications

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

related product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Amino Acids, Peptides and Proteins in Organic Chemistry (2013)
A functional study on the migration of human monocytes to human leukemic cell lines and the role of monocyte chemoattractant protein-1.
Legdeur MC et al.
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Assessment of the sensitizing potential of processed peanut proteins in Brown Norway rats: roasting does not enhance allergenicity.
Kroghsbo S et al.
PLoS ONE, 9, e96475-e96475 (2014)
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Kalina WV et al.
Vaccine, 22, 1465-1465 (2004)
B López-Corcuera et al.
Molecular membrane biology, 18(1), 13-20 (2001-06-09)
Glycine accomplishes several functions as a transmitter in the central nervous system (CNS). As an inhibitory neurotransmitter, it participates in the processing of motor and sensory information that permits movement, vision, and audition. This action of glycine is mediated by

Protocols

Enzymatic Assay of Phytase (EC 3.1.3.8)

Derived from procedure SSPHYT02. Includes template updates to current SOP specifications and incorporation of notes into the procedure.

Enzymatic Assay and ATP Sensitivity Test of Luciferase

To measure luciferase activity, an assay that measures light emission with a luminometer is used. Firefly luciferase is used for detection and quantitation of ATP and as a reporter for genetic function.

Enzymatic Assay of 5’-Nucleotidase

To measure 5′-nucleotidase activity, this procedure uses adenosine 5’-monophosphate and a color reagent to create a standard curve for determining the micromoles of phosphorus liberated.

Enzymatic Assay of β-Glucuronidase (EC 3.2.1.31) from E. coli

Objective: To standardize a procedure for the enzymatic assay of β-Glucuronidase.

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