410225

Glycine

≥98.5%, ACS reagent for peptide synthesis

• Synonym(s): Aminoacetic acid, Aminoethanoic acid, Glycocoll
• Linear Formula: NH₂CH₂COOH
• CAS Number: 56-40-6
• Molecular Weight: 75.07
• Beilstein/REAXYS Number: 635782
• EC Number: 200-272-2
• MDL number: MFCD00008131
• UNSPSC Code: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 24865701
• NACRES: NA.21

Properties

• Product Name: Glycine, ACS reagent, ≥98.5%
• grade: ACS reagent
• Quality Level: 200
• assay: ≥98.5%
• form: powder, crystals or granules
• impurities: H₂SO₄, passes test (darkened); Hydrolyzable subsances, passes test
• ign. residue: ≤0.1%
• color: white
• pKa (25 °C): (1) 2.35, (2) 9.60; 2.35
• mp: 240 °C (dec.) (lit.)

Description

General description

Glycine is the simplest amino acid building block.

Application

Glycine has been used in whole-cell patch clamp recording to measure inward NMDA (N-methyl-D-aspartate) currents.[1] It has also been used as a model organic system in crystallography to demonstrate a novel acoustic nebulization platform.[2]

Biochem/physiol Actions

Glycine is a non-essential amino acid.[3] Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors.[4] Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid.[3]

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)