MilliporeSigma

1.00243

SAFC

Citric acid monohydrate

powder, EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, JP, USP, FCC, E 330

Synonym(s):
2-Hydroxypropane-1,2,3-tricarboxylic acid, Hydroxytricarballylic acid
Linear Formula:
HOC(COOH)(CH2COOH)2 · H2O
CAS Number:
Molecular Weight:
210.14
Beilstein:
4018641
MDL number:
E Number:
E330
EC Index Number:
201-069-1

Agency

BP
ChP
JP
Ph. Eur.
USP

Quality Level

reg. compliance

FCC

vapor pressure

<1 Pa ( 25 °C)

product line

EMPROVE® ESSENTIAL

form

fine powder
powder

potency

3000 mg/kg LD50, oral (Rat)

particle size

(see specification)

pH

1.85 (25 °C, 50 g/L in H2O)

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

mp

135-152 °C

transition temp

flash point 173.9 °C

solubility

880 g/L

density

1.54 g/cm3 at 20 °C

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

2-30°C

SMILES string

OC(CC(O)(C(O)=O)CC(O)=O)=O.O

InChI

1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2

InChI key

YASYEJJMZJALEJ-UHFFFAOYSA-N

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This Item
1.002441.370031.00242
Citric acid monohydrate powder, EMPROVE&#174; ESSENTIAL, Ph. Eur., BP, ChP, JP, USP, FCC, E 330

SAFC

1.00243

Citric acid monohydrate

Citric acid monohydrate for analysis EMSURE&#174; ACS,ISO,Reag. Ph Eur

Supelco

1.00244

Citric acid monohydrate

Citric acid monohydrate crystalline, EMPROVE&#174; EXPERT, Ph. Eur., BP, JP, USP, ACS

SAFC

1.37003

Citric acid monohydrate

Citric acid monohydrate crystalline, EMPROVE&#174; ESSENTIAL, Ph. Eur., BP, ChP, USP, FCC, E 330

SAFC

1.00242

Citric acid monohydrate

vapor pressure

<1 Pa ( 25 °C)

vapor pressure

<1 Pa ( 25 °C)

vapor pressure

<1 Pa ( 25 °C)

vapor pressure

<1 Pa ( 25 °C)

form

fine powder

form

solid

form

crystalline, solid

form

coarse powder, crystalline

pH

1.85 (25 °C, 50 g/L in H2O)

pH

1.85 (25 °C, 50 g/L in H2O)

pH

1.85 (25 °C, 50 g/L in H2O)

pH

1.85 (25 °C, 50 g/L in H2O)

mp

135-152 °C

mp

135-152 °C

mp

135-152 °C

mp

135-152 °C

solubility

880 g/L

solubility

880 g/L

solubility

880 g/L

solubility

880 g/L

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Citric acid is typically used as pH adjuster, buffer agent or as antioxidant in pharmaceutical formulations. Its application range spans across different formulation types, including semi-solid dosage forms, liquid dosage forms such as solutions and solid dosage forms such as effervescent tablets or granules.
Citric acid monohydrate powder Emprove® Essential is citric acid present in its monohydrate, powder form.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

345.0 °F - closed cup

Flash Point(C)

173.9 °C - closed cup


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