MilliporeSigma

1.06386

SAFC

Sodium carbonate monohydrate

EMPROVE® ESSENTIAL, Ph. Eur., BP, NF, E 500

Synonym(s):
Sodium carbonate monohydrate, Soda monohydrate, Sodium Carbonate Monohydrate
Empirical Formula (Hill Notation):
CNa2O3 · xH2O
CAS Number:
Molecular Weight:
105.99 (anhydrous basis)
MDL number:
E Number:
E500
EC Index Number:
207-838-8

Agency

BP
NF
Ph. Eur.

Quality Level

product line

EMPROVE® ESSENTIAL

form

solid

pH

11-12 (25 °C, 50 g/L in H2O)

mp

854 °C (anhydrous substance)

density

2.25 g/cm3 at 20 °C

application(s)

liquid formulation
pharmaceutical
solid formulation

storage temp.

2-30°C

InChI

1S/CH2O3.2Na.H2O/c2-1(3)4;;;/h(H2,2,3,4);;;1H2/q;2*+1;/p-2

InChI key

MQRJBSHKWOFOGF-UHFFFAOYSA-L

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This Item
1.063841.063981.37093
Sodium carbonate monohydrate EMPROVE® ESSENTIAL, Ph. Eur., BP, NF, E 500

SAFC

1.06386

Sodium carbonate monohydrate

Sodium carbonate decahydrate EMPROVE® ESSENTIAL, Ph. Eur., BP, E 500

SAFC

1.06384

Sodium carbonate decahydrate

Sodium carbonate anhydrous, EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, JP, NF

SAFC

1.06398

Sodium carbonate

pH

11-12 (25 °C, 50 g/L in H2O)

pH

11-12 (25 °C, 50 g/L in H2O)

pH

11.16 (25 °C, 4 g/L in H2O)

pH

4.1-4.5 (25 °C, 50 g/L in H2O)

mp

854 °C (anhydrous substance)

mp

33 °C (Elimination of water of crystallisation)

mp

851 °C (lit.)

mp

-

density

2.25 g/cm3 at 20 °C

density

1.44 g/cm3 at 20 °C

density

2.53 g/cm3 at 20 °C

density

2.04 g/cm3 at 20 °C

Quality Level

500

Quality Level

500

Quality Level

500

Quality Level

500

agency

BP

agency

BP, Ph. Eur.

agency

BP, ChP, JP, NF, Ph. Eur.

agency

BP, ChP, USP

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Sodium carbonate is a commonly used ingredient in both food and pharmaceutics. In pharmaceutical applications, sodium carbonate is used as pH adjuster, or a source of carbon dioxide in oral formulations such as effervescent tablets or granules.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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