MilliporeSigma

1.06323

SAFC

Sodium hydrogen carbonate

EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, JP, USP, FCC, E 500

Synonym(s):
Sodium bicarbonate
Linear Formula:
NaHCO3
CAS Number:
Molecular Weight:
84.01
Beilstein:
4153970
MDL number:
E Number:
E500
EC Index Number:
205-633-8

Agency

BP
ChP
JP
Ph. Eur.
USP

Quality Level

reg. compliance

FCC

product line

EMPROVE® ESSENTIAL

form

solid

pH

8.6 (20 °C, 50 g/L in H2O)

pKa (25 °C)

(1) 6.37, (2) 10.25 (carbonic acid)

mp

270 °C (decomposition)

solubility

96 g/L

density

2.22 g/cm3 at 20 °C
2.16 g/mL at 25 °C (lit.)

application(s)

liquid formulation
ophthalmics
pharmaceutical
solid formulation

storage temp.

2-30°C

SMILES string

[Na+].OC([O-])=O

InChI

1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1

InChI key

UIIMBOGNXHQVGW-UHFFFAOYSA-M

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This Item
1.063981.063861.01131
Sodium hydrogen carbonate EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, USP, FCC, E 500

SAFC

1.06323

Sodium hydrogen carbonate

Sodium carbonate anhydrous, EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, JP, NF

SAFC

1.06398

Sodium carbonate

Sodium carbonate monohydrate EMPROVE® ESSENTIAL, Ph. Eur., BP, NF, E 500

SAFC

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Sodium carbonate monohydrate

Ammonium hydrogen carbonate EMPROVE® ESSENTIAL, Ph. Eur., BP, E 503

SAFC

1.01131

Ammonium hydrogen carbonate

pH

8.6 (20 °C, 50 g/L in H2O)

pH

11.16 (25 °C, 4 g/L in H2O)

pH

11-12 (25 °C, 50 g/L in H2O)

pH

8 (20 °C, 50 g/L in H2O)

mp

270 °C (decomposition)

mp

851 °C (lit.)

mp

854 °C (anhydrous substance)

mp

106 °C

solubility

96 g/L

solubility

212.5 g/L

solubility

-

solubility

-

density

2.22 g/cm3 at 20 °C, 2.16 g/mL at 25 °C (lit.)

density

2.53 g/cm3 at 20 °C

density

2.25 g/cm3 at 20 °C

density

-

Quality Level

500

Quality Level

500

Quality Level

500

Quality Level

500

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Sodium hydrogen carbonate is a commonly used ingredient in both food and pharmaceutics. In pharmaceutical applications, sodium hydrogen carbonate is used as pH adjuster, or a source of carbon dioxide in oral formulations such as effervescent tablets or granules.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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