Skip to Content
MilliporeSigma

1.37003

SAFC

Citric acid monohydrate

crystalline, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

Pharma Manufacturing

Synonym(s):

2-Hydroxypropane-1,2,3-tricarboxylic acid, Hydroxytricarballylic acid

Sign Into View Organizational & Contract Pricing


About This Item

Linear Formula:
HOC(COOH)(CH2COOH)2 · H2O
CAS Number:
Molecular Weight:
210.14
Beilstein/REAXYS Number:
4018641
MDL number:
UNSPSC Code:
12352106
EC Index Number:
201-069-1

agency

BP
ChP
JP
Ph. Eur.
USP

Quality Level

vapor pressure

<1 Pa ( 25 °C)

description

cryst. EMPROVE® EXPERT Ph Eur,BP,ChP,JP,USP

product line

EMPROVE® EXPERT

form

crystalline
solid

feature

RNase and DNase free

pH

1.85 (25 °C, 50 g/L in H2O)

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

mp

135-152 °C

transition temp

flash point 173.9 °C

solubility

880 g/L

density

1.54 g/cm3 at 20 °C

application(s)

liquid formulation
parenterals
pharma/biopharma processes
pharmaceutical

storage temp.

15-25°C

SMILES string

OC(CC(O)(C(O)=O)CC(O)=O)=O.O

InChI

1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2

InChI key

YASYEJJMZJALEJ-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Citric acid anhydrous is typically used as a citrate buffer system component for biomolecule downstream chromatography steps or final liquid formulation.
Due to its low microbial and endotoxin limits, Citric acid anhydrous Emprove® Expert is especially suitable for high-risk applications.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 1

flash_point_f

345.0 °F

flash_point_c

173.9 °C


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Related Content

Learn more on mAb subcutaneous or intravenous formulation, and the relevant associated products, including excipients.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service