MilliporeSigma
All Photos(3)

1.06574

SAFC

di-Sodium hydrogen phosphate heptahydrate

EMPROVE® ESSENTIAL, DAC, USP

Synonym(s):
Sodium phosphate dibasic heptahydrate, Disodium hydrogen phosphate heptahydrate, Disodium phosphate
Linear Formula:
Na2HPO4 · 7H2O
CAS Number:
Molecular Weight:
268.07
MDL number:
EC Index Number:
231-448-7

Agency

DAC
USP

Quality Level

vapor density

4.9 (vs air)

product line

EMPROVE® ESSENTIAL

form

solid

pH

8.7-9.3 (25 °C, 50 g/L in H2O)

mp

48 °C (Elimination of water of crystallisation)

solubility

154 g/L

density

1.68 g/mL at 25 °C (lit.)

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

2-30°C

SMILES string

O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O

InChI

1S/2Na.H3O4P.7H2O/c;;1-5(2,3)4;;;;;;;/h;;(H3,1,2,3,4);7*1H2/q2*+1;;;;;;;;/p-2

InChI key

PYLIXCKOHOHGKQ-UHFFFAOYSA-L

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This Item
1.37092S2429S9390
form

solid

form

solid

form

powder, crystals or chunks

form

powder

pH

8.7-9.3 (25 °C, 50 g/L in H2O)

pH

8.7-9.3 (25 °C, 50 g/L in H2O)

pH

9.0-9.3 (25 °C, 50 g/L)

pH

8.7-9.3 (25 °C, 5% in solution)

mp

48 °C (Elimination of water of crystallisation)

mp

48 °C (Elimination of water of crystallisation)

mp

-

mp

-

solubility

154 g/L

solubility

-

solubility

water: ~35.8 g/L at 20 °C

solubility

-

density

1.68 g/mL at 25 °C (lit.)

density

1.68 g/mL at 25 °C (lit.)

density

1.68 g/mL at 25 °C (lit.)

density

1.68 g/mL at 25 °C (lit.)

Quality Level

500

Quality Level

500

Quality Level

300

Quality Level

100

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

di-Sodium hydrogen phosphate heptahydrate is typically used as a phosphate buffer system component for biomolecule downstream chromatography steps or final liquid formulation.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials. Four document types are included with an Emprove® Program subscription:

Material Qualification Dossier

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Quality Management Dossier (Open Access)

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Operational Excellence Dossier

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Why are these documents unavailable?
Emprove® Dossiers contain information intended to support the registration process and risk assessment activities of pharmaceutical producers and contain confidential information. Please contact us if you would like access.

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