1.10110

2-[4-(2-Hydroxyethyl)-1-piperazinyl]-ethanesulfonic acid

Buffer substance HEPES EMPROVE^® EXPERT

• Synonym(s): HEPES, 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid, N-(2-Hydroxyethyl)piperazine-N′-(2-ethanesulfonic acid)
• Empirical Formula (Hill Notation): C₈H₁₈N₂O₄S
• CAS Number: 7365-45-9
• Molecular Weight: 238.30
• Beilstein/REAXYS Number: 883043
• MDL number: MFCD00006158
• UNSPSC Code: 12161703
• EC Index Number: 230-907-9

Properties

• Quality Level: 500
• product line: EMPROVE^® EXPERT
• potency: >2000 mg/kg LD₅₀, oral (Rat)
• feature: RNase and DNase free
• technique(s): API processing | cocrystal formation: suitable
• pH: 5.0-5.5 (20 °C, 100 g/L in H₂O)
• useful pH range: 6.8-8.2
• pKa (25 °C): 7.5
• mp: 212.6 °C
• solubility: 703.6 g/L
• density: 1.44 g/cm³ at 20 °C
• bulk density: 560 kg/m³
• storage temp.: 2-25°C
• SMILES string: OCCN1CCN(CC1)CCS(O)(=O)=O
• InChI: 1S/C8H18N2O4S/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14/h11H,1-8H2,(H,12,13,14)
• InChI key: JKMHFZQWWAIEOD-UHFFFAOYSA-N

Description

General description

Our SAFC^® portfolio of high-quality products for biopharmaceutical processing withstands strict quality control procedures and is produced according to MQ-500 requirements as defined by the M-Clarity program.

M-Clarity Program

As part of our EMPROVE^® Program, our raw materials are offered with EMPROVE^® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.
Buffer quality is vital for the success of biopharmaceutical processes, because buffers are indispensable in nearly every production step.

Our broad portfolio of buffer materials manufactured under appropriate controls is tailored to your needs. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable