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Benzonase® Salt Tolerant Endonuclease

greener alternative

EMPROVE® EXPERT

Pharma Manufacturing

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About This Item

UNSPSC Code:
12352204

product line

EMPROVE® EXPERT

Quality Level

500

greener alternative product characteristics

Waste Prevention
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

application(s)

pharma/biopharma processes

greener alternative category

DfS-Developed

storage temp.

−20°C

Related Categories

General description

The best-in-class solution for nucleic acid removal at high salt concentration in Bioprocessing
We are committed to bringing you Greener AlternativeProducts, which belongs to one of the four categories of greener alternatives .This product is a Design for Sustainability (DfS) developed product. Click hereto view its DfS scorecard.

Application

The Benzonase® Salt Tolerant endonuclease Emprove® Expert is a new enzyme, different in amino acids sequence from other Benzonase® endonuclease references. It was designed with state-of-the-art protein engineering capabilities, to ensure the highest activity at high salt concentrations. The protein is a monomer with a molecular weight of about 27 kDa . The protein has an isoelectric point (pI) at pH 9.68. It is functional between pH 6 and 10, and from 0 °C to above 37 °C. Mg2+ (1–2 mM) is required for enzyme activity.

Packaging

  • 80,000 Units
  • 400,000 Units
  • 4,000,000 Units + 40, 000 Units tailgate sample

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

Certificates of Analysis (COA)

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Articles

AAV Process Intensification Using High Salt Lysis and Salt Tolerant Endonuclease

This page describes key considerations for cell lysis and how the combination of a high salt concentration and a salt tolerant endonuclease can be used to increase vector titer and infectivity during AAV vector manufacturing.

DNA/RNA Removal in Viral Production

Benzonase®endonuclease efficiently removes nucleic acid contaminants from viral production, crucial for cell and gene therapies and vaccines.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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