MilliporeSigma

1.42020

SAFC

Cyclodextrin HPB

EMPROVE® EXPERT, Ph. Eur., NF

Synonym(s):
Cyclodextrin HPB, (2-Hydroxypropyl)-β-Cyclodextrin, HP-B-CD, Hydroxypropyl Betadex
Linear Formula:
C42H70-nO35 · (C3H7O)n
CAS Number:

Agency

NF
Ph. Eur.

Quality Level

product line

EMPROVE® EXPERT

form

solid

mol wt

avg mol wt 1387.2 g/mol

pH

5.0-7.0 (20 g/L in H2O)

solubility

450 g/L

application(s)

liquid formulation
ophthalmics
pharmaceutical
solid formulation
solubility enhancement

storage temp.

15-25°C

General description

When working on a pharmaceutical formulation, there are specific considerations to make and challenging hurdles to take before you can successfully launch your final drug product - formulation stability, release kinetics and bioavailability limitations just to name a few. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Cyclodextrin HPB (hydroxypylated β-cyclodextrin) can be used to strongly increase solubility of active pharmaceutical ingredients (APIs) by forming API:cyclodextrin inclusion complexes. It can also increase API stability and safety as well as mask undesired odors and tastes. The broad application range of Cyclodextrin HPB comprises liquid, semi-solid and solid formulations, as well as diverse routes of administration. Due to its low microbial and endotoxin limits, Cyclodextrin HPB Emprove® Expert is especially suitable for high-risk applications.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

752.0 °F

Flash Point(C)

> 400 °C


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Customers Also Viewed

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Betadex European Pharmacopoeia (EP) Reference Standard

B0950000

Betadex

α-Cyclodextrin ≥98%

Sigma-Aldrich

C4642

α-Cyclodextrin

γ-Cyclodextrin ≥98%

Sigma-Aldrich

C4892

γ-Cyclodextrin

β-Cyclodextrin ≥97%

Sigma-Aldrich

C4767

β-Cyclodextrin

Articles

Overcoming Excipient Risks and Challenges for Parenteral Formulations

This overview describes the challenges when developing parenteral formulations and strategies to overcome them and reduce the risk of production.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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