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1.51450

Supelco

Chromolith® RP-18 endcapped

L × I.D.50 mm x 4.6 mm HPLC column

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Synonym(s):
Chromolith® SpeedROD RP-18 endcapped 50-4.6 HPLC column

material

PEEK column

Quality Level

agency

suitable for USP L1

product line

Chromolith®

feature

endcapped

packaging

1 ea of

extent of labeling

18% Carbon loading

parameter

200 bar pressure
45 °C max. temp.

technique(s)

HPLC: suitable
LC/MS: suitable
mass spectrometry (MS): suitable (High)

column L × I.D.

5 cm × 4.6 mm

matrix

monolithic silica

matrix active group

C18 bonding phase

pore size

13 nm mesoporosity
2 μm macroporosity

operating pH range

2-7.5

separation technique

reversed phase

storage temp.

no temp limit

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1 of 4

This Item
1.520071.514631.52006
Chromolith® RP-18 endcapped L × I.D.50 mm x 4.6 mm HPLC column

1.51450

Chromolith® RP-18 endcapped

Chromolith® RP-18 endcapped L × I.D. 50 mm x 2 mm HPLC column

1.52007

Chromolith® RP-18 endcapped

Chromolith® RP-18 endcapped L × I.D. 25 mm x 4.6 mm HPLC column

1.51463

Chromolith® RP-18 endcapped

Chromolith® RP-18 endcapped L × I.D. 100 mm x 2 mm HPLC column

1.52006

Chromolith® RP-18 endcapped

matrix active group

C18 bonding phase

matrix active group

C18 bonding phase

matrix active group

C18 bonding phase

matrix active group

C18 bonding phase

matrix

monolithic silica

matrix

monolithic silica

matrix

monolithic silica

matrix

monolithic silica

pore size

13 nm mesoporosity, 2 μm macroporosity

pore size

1.5 μm macroporosity, 13 nm mesoporosity

pore size

13 nm mesoporosity, 2 μm macroporosity

pore size

1.5 μm macroporosity, 13 nm mesoporosity

agency

suitable for USP L1

agency

suitable for USP L1

agency

suitable for USP L1

agency

suitable for USP L1

technique(s)

HPLC: suitable, mass spectrometry (MS): suitable (High), LC/MS: suitable

technique(s)

LC/MS: suitable, UHPLC-MS: suitable, UHPLC: suitable, mass spectrometry (MS): suitable (High)

technique(s)

HPLC: suitable, LC/MS: suitable, mass spectrometry (MS): suitable (High)

technique(s)

HPLC: suitable, LC/MS: suitable, UHPLC-MS: suitable, UHPLC: suitable, mass spectrometry (MS): suitable (High)

General description

Chromolith® columns are made of monolithic silica with a characteristic bimodal pore structure.

Chromolith® SpeedROD RP-18 endcapped columns have macropores with 2 μm diameter, giving a column efficiency exceeding 80,000 plates/meter. The mesopores are 13 nm (130 Å), the surface modification is octadecylsilane with full end-capping. Chromolith® SpeedROD RP-18 endcapped columns fall under the USP L1 Classification. The column efficiency is comparable to a 5 μm particle size fully porous particulate column. Chromolith® SpeedROD RP-18 endcapped columns are perfectly suitable for LC-MS applications.
The column dimension of 50 mm length and 4.6 mm I.D. is the best choice for fast separations on any HPLC System.

The revolutionary, monolithic silica with its unique combination of macropores and mesopores enables:
—Rapid separations at very low column back-pressure
—High matrix tolerance, allowing time and cost savings with simplified workflows
—Cost-savings due to extended column lifetimes
—Connection of columns, flow gradients and the use of mobile phases with higher viscosity

The recommended Guard-columns are:
Chromolith® RP-18 endcapped 5-4.6 guard cartridges (3 pieces) [1.51452] with the Chromolith® Guard Cartridge Holder 5 mm x 4.6 mm [1.52032]
Or
Chromolith® RP-18 endcapped 10-4.6 guard cartridges (3 pieces) [1.51451]
Guard Cartridge Holder 10 mm x 4.6 mm [1.52033]
The Chromolith® column coupler can be used to significantly increase the separation efficiency of Chromolith® columns by coupling several columns in series (up to 100,000 plates/per column). [1.51467]

Need more efficiency?
Chromolith® HighResolution RP-18 endcapped 50-4.6 HPLC columns [1.52021] provide a column efficiency exceeding 140,000 plates/meter.

Learn more:
Brochure: Race through your Separations on Any System. Chromolith® Monolithic Silica HPLC Columns

All Supelco HPLC Columns, including monolithic Chromolith® columns, are fully compatible to all HPLC and UHPLC Instruments.
Supelco HPLC Products: The Best Choice for Any LC Instrument

Analysis Note

Carbon content: 17.0 - 18.6 %
Pressure: ≤ 15 bar
stability testing: passes test
Performance (anthracene)
Theoretical Plates (N/m) (Anthracene): ≥ 80000
Capacity factor (Anthracene): 3.6 - 4.6
Tailing (USP): 0.90 - 1.55 %
Selectivity
separation factor (anthracene/progesterone): 1.95 - 2.35

Legal Information

Chromolith is a registered trademark of Merck KGaA, Darmstadt, Germany

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Articles

Monolithic silica HPLC columns enable high-throughput analysis at low back pressure without loss of separation efficiency or peak capacity.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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