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234109-M

Millipore

Colcemid

Cell synchronization agent.

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Synonym(s):
Colcemid, Demecolcine
Empirical Formula (Hill Notation):
C21H25NO5
CAS Number:
Molecular Weight:
371.43
MDL number:

Assay

≥98% (HPLC)

form

crystalline powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

chloroform: 10 mg/mL
ethanol: soluble

storage temp.

10-30°C

InChI

1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3

InChI key

NNJPGOLRFBJNIW-UHFFFAOYSA-N

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This Item
102958920015.33916234115
Colcemid Cell synchronization agent.

Millipore

234109-M

Colcemid

Colcemid solution, suitable for blocking, sterile; 0.2 μm filtered

Roche

10295892001

Colcemid

form

crystalline powder

form

solution

form

film

form

powder

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Roche

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

storage condition

-

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

solubility

chloroform: 10 mg/mL, ethanol: soluble

solubility

water: miscible

solubility

DMSO: 50 mg/mL

solubility

ethanol: 10 mg/mL, water: soluble

storage temp.

10-30°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

10-30°C

General description

Cell synchronization agent. Induces apoptosis by blocking mitosis in HeLa S3 cells. Depolymerizes microtubules and limits microtubule formation. Appropriate dilutions inactivate spindle fiber mechanism during metaphase, systematically immobilizing chromosomes at the metaphase plate.
Cell synchronization agent. Induces apoptosis by blocking mitosis in HeLa S3 cells. Depolymerizes microtubules and limits microtubule formation. Appropriate dilutions inactivate the spindle fiber mechanism during metaphase, systematically immobilizing chromosomes at the metaphase plate.

Biochem/physiol Actions

Primary Target
Depolymerizes microtubules and limits microtubule formation.

Warning

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
Kanda, R., et al. 1994. J. Radiat. Res. 35, 41.
Sherwood, S.W., et al. 1994. Exp. Cell Res. 215, 373.
Nishiyama, I., and Fuji, T. 1992. Exp. Cell Res.198, 214.
Spoerri, P.E., and Roisen, F.J. 1992. J. Neurosci. Res.31, 494.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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