252926

N-Acetylneuraminic Acid, 2,3-Dehydro-2-deoxy-, Sodium Salt

Inhibitor of bacterial, viral, and mammalian neuraminidases. Ki = 4 µM for influenza virus neuraminidase. Believed to act by binding to the catalytic site of neuraminidase as a transition state analog.

• Synonym(s): N-Acetylneuraminic Acid, 2,3-Dehydro-2-deoxy-, Sodium Salt
• Empirical Formula (Hill Notation): C₁₁H₁₆NNaO₈
• Molecular Weight: 313.24
• UNSPSC Code: 12352201
• NACRES: NA.79

Properties

• Quality Level: 100
• assay: ≥95% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: off-white to pale yellow
• solubility: water: 1 mM
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A ganglioside neuraminidase inhibitor that is believed to act by binding to the catalytic site of neuraminidase. Reported to inhibit influenza virus neuraminidase (K_i = 4 µM). Also inhibits bacterial, viral, and mammalian neuraminidases.

Inhibitor of bacterial, viral, and mammalian neuraminidases. K_i = 4 µM for influenza virus neuraminidase. Believed to act by binding to the catalytic site of neuraminidase as a transition state analog.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Kopitz, J., et al. 1997. Eur. J. Cell. Biol.73, 1.
Holzer, C.T., et al. 1993. Glycoconj. J.10, 40.
Chong, A.K., et al. 1991. Biochem. Int.24, 165.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable