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481975

Sigma-Aldrich

(--)-Nicotine, Ditartrate

Potent agonist of the nicotinic acetylcholine receptor.

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Synonym(s):
(--)-Nicotine, Ditartrate, (S)-3-(1-Methyl-2-pyrrolindinyl)pyridine, Di- d-tartrate, (S)-3-(1-Methyl-2-pyrrolindinyl)pyridine, Di-d-tartrate
Empirical Formula (Hill Notation):
C10H14N2 · 2C4H6O6
CAS Number:
Molecular Weight:
462.41

Quality Level

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white to off-white

solubility

ethanol: 10 mg/mL
water: 10 mg/mL

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C10H14N2.2C4H6O6/c1-12-7-3-5-10(12)9-4-2-6-11-8-9;2*5-1(3(7)8)2(6)4(9)10/h2,4,6,8,10H,3,5,7H2,1H3;2*1-2,5-6H,(H,7,8)(H,9,10)/t;2*1-,2-/m.11/s1

InChI key

RFEJUZJILGIRHQ-WBPXWQEISA-N

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This Item
N3876SML1236489350
(--)-Nicotine, Ditartrate Potent agonist of the nicotinic acetylcholine receptor.

481975

(--)-Nicotine, Ditartrate

(−)-Nicotine ≥99% (GC), liquid

N3876

(−)-Nicotine

form

solid

form

liquid

form

powder

form

crystalline solid

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

storage temp.

10-30°C

storage temp.

-

storage temp.

room temp

storage temp.

2-8°C

storage condition

OK to freeze

storage condition

-

storage condition

desiccated

storage condition

OK to freeze, desiccated

General description

Potent agonist of the nicotinic acetylcholine receptor. Stimulates autonomic ganglia and skeletal muscle neuromuscular junctions.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Nicotinic acetylcholine receptor
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Highly Toxic (H)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 6 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Rand, M.J. 1989. Prog. Brain Res. 79, 3.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2

Storage Class

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 2

flash_point_f

289.8 °F

flash_point_c

143.2 °C


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Yan Wang et al.
Oncology reports, 40(4), 2097-2104 (2018-07-18)
Store‑operated calcium entry (SOCE) is critical for regulating the proliferation and metastasis of various cancer types. The present study aimed to investigate the role of SOCE on nicotine‑promoted proliferation of non‑small cell lung cancer (NSCLC) A549 cells. Cell proliferation was

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