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MilliporeSigma

5.00111

SAFC

Cocarboxylase tetrahydrate

(thiamine pyrophosphate tetrahydrate), EMPROVE® API

Pharma Manufacturing

Synonym(s):

Cocarboxylase tetrahydrate

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200 MG
$1,870.00

$1,870.00


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200 MG
$1,870.00

About This Item

Empirical Formula (Hill Notation):
C12H18N4O7P2S · 4H2O
CAS Number:
Molecular Weight:
496.37
MDL number:
UNSPSC Code:
12352107
EC Index Number:
205-230-7

$1,870.00


In StockDetails


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Quality Level

product line

EMPROVE® API

form

solid

pH

2.4-3.2 (20 °C, 100 g/L in H2O)

solubility

55 g/L

bulk density

450 kg/m3

application(s)

liquid formulation
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

2-25°C

SMILES string

[P](=O)([O-])(O[P](=O)([O-])O)OCCc1[s]c[n+](c1C)Cc2c(nc(nc2)C)N.O.O.O.O.[H+]

InChI

1S/C12H18N4O7P2S.4H2O/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13;;;;/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21);4*1H2

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Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879)

Gene Information

-

Gene Information

human ... BZRAP1(9256), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879)
rat ... Gabra2(29706), Gabrg1(140674)

Gene Information

-

General description

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. As part of our EMPROVE® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Cocarboxylase tetrahydrate Emprove® API is a source for Vitamin B1 for use in clinical nutrition, vitamin supplements and infusion for Vitamin B1 deficiency. Cocarboxylase Tetrahydrate (thiamine diphosphoric acid ester tetrahydrate) Emprove® API is manufactured according to ICH Q7 guidelines. An ASMF is available.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

The substance 5.00111 has no REACH registration because the only supported use is the use in medicinal products for human or veterinary use or in food or feedingstuffs according to article 2 of the REACH Regulation (EC) No 1907/2006.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials. Four document types are included with an Emprove® Program subscription:

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Why are these documents unavailable?
Emprove® Dossiers contain information intended to support the registration process and risk assessment activities of pharmaceutical producers and contain confidential information. Please contact us if you would like access.

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