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5.34337

Sigma-Aldrich

CADA

≥98% (HPLC), solid, HIV inhibitor, Calbiochem®

Synonym(s):

HIV Inhibitor, CADA, 1-Benzyl-7-methylene-5,9-ditosyl-5,9-diaza-azoniacyclododecan-1-ium chloride, CD4 Inhibitor, CADA

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1 EA
$459.00

$459.00


Estimated to ship onMarch 23, 2025



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1 EA
$459.00

About This Item

Empirical Formula (Hill Notation):
C31H39N3O4S2 · xHCl
Molecular Weight:
581.79 (free base basis)
UNSPSC Code:
51111800
NACRES:
NA.77

$459.00


Estimated to ship onMarch 23, 2025


Product Name

HIV Inhibitor, CADA,

assay

≥98% (HPLC)

Quality Level

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 10 mg/mL
water: insoluble

storage temp.

−20°C

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This Item
P4153M0639H4881
assay

≥98.00% (TLC)

assay

≥90%

assay

≥98%

assay

≥90% (HPLC)

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

technique(s)

toxicology assay: suitable

technique(s)

-

technique(s)

-

technique(s)

-

storage temp.

room temp

storage temp.

−20°C

storage temp.

room temp

storage temp.

−20°C

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

solubility

water: 50 mg/mL, clear, colorless

solubility

chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

General description

A cell-permeable macrocyle cyclotriazadisulfonamide derivative compound that inhibits HIV replication (IC50 = 300 nM to 3.3 µM) and entry into cells by blocking co-translational translocation of nascent CD4 across endoplasmic reticulum membranes. Its action appears to be highly selective in reducing the expression of human CD4 and it does not affect the level of any other cell surface marker studied. Does not affect CD4 mRNA levels in cells. Shown to be effective against HIV-1 subtypes A to H, AE, and O and human herpesvirus 7 (HHV-7; IC50, 300 nM to 1.5 µM) in T-cell lines and PBMCs. Also reported to block X4 HIV-1 NL4.3 and R5 SIVmac251 laboratory strains infection in human T cells. Can act synergistically with cellulose acetate phthalate (CAP) and other anti-HIV drugs to inhibit HIV-1 and SIV infections.

Biochem/physiol Actions

Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Vermeire, K., et al. 2008. Curr. HIV Res.6, 246.
Bell, T. W., et al. 2006. J. Med. Chem.49, 1291.
Vermeire, K., et al. 2004. AIDS.18, 2115.
Vermeire, K., et al. 2002. Virology.302, 342.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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