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Serine/Threonine Kinase Inhibitor Set

The Serine/Threonine Kinase Inhibitor Set controls the biological activity of Serine/Threonine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

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Quality Level

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

solubility

DMSO: 1 mg/mL (all other inhibitors)
water: 1 mg/mL (Protein Kinase G Inhibitor)

shipped in

ambient

storage temp.

−20°C

General description

A convenient set that offers several highly selective serine/threonine kinase inhibitors. Kinases play an important role in numerous signaling cascades. Highly selective protein kinase inhibitors are useful for dissecting these cascades to determine which specific kinases are involved in producing particular biological effects. The Serine/Threonine Kinase Inhibitor Set contains the following highly selective serine/ threonine kinase inhibitors in one convenient set:



• Bisindolylmaleimide I (Cat. No. 203290), 250 µg

• H-89, Dihydrochloride (Cat. No. 371963), 1 mg

• KN-93 (Cat. No. 422708), 1 mg

• ML-7 (Cat. No. 475880), 1 mg

• Protein Kinase G Inhibitor (Cat. No. 370654), 1 mg

• Staurosporine (Cat. No. 569397), 100 µg

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PKA
Secondary Target
PKC, MLCK, Cam kinase II, PKG

Warning

Toxicity: Multiple Toxicity Values, refer to MSDS (O)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions of each inhibitor are stable for up to 3 months at -20°C.

Other Notes

Martiny, G., et al. 1993. J. Biol. Chem.268, 9194.
Toullec, D., et al. 1991. J. Biol. Chem.266, 15771.
Chijiwa, T., et al. 1990. J. Biol. Chem.265, 5267.
Simu, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 968.
Saitoh, M., et al. J. Biol. Chem.262, 7796.
Glass, D.B., et al. 1983. Biochem. J.213, 159.
Seynaeve, C.M., et al. 1994. Mol. Pharmacol.45, 1207.
Meyer, T., et al. 1989. Int. J. Cancer43, 851.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazard

signalword

Warning

Hazard Classifications

Aquatic Chronic 4 - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3


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