5.43899

NMP

for liquid chromatography LiChrosolv^®

• Synonym(s): 1-Methyl-2-pyrrolidone, NMP, N-Methyl-2-pyrrolidone
• Empirical Formula (Hill Notation): C₅H₉NO
• CAS Number: 872-50-4
• Molecular Weight: 99.13
• MDL number: MFCD00003193
• UNSPSC Code: 41116105
• EC Index Number: 212-828-1
• NACRES: NA.03

Properties

• product name: 1-Methyl-2-pyrrolidone, for liquid chromatography LiChrosolv^®
• vapor pressure: 0.32 hPa ( 20 °C)
• Quality Level: 100
• product line: LiChrosolv^®
• grade: isocratic
• assay: ≥99.5% (GC)
• form: liquid
• autoignition temp.: 245 °C
• expl. lim.: 1.3-9.5 % (v/v)
• technique(s): HPLC: suitable
• impurities: ≤0.05% Water
• transmittance: 300 nm, ≥50%; 325 nm, ≥90%; 350 nm, ≥97%; 400 nm, ≥99%
• pH: 8.5-10.0 (20 °C, 100 g/L in H₂O)
• bp: 202 °C/1013 hPa
• mp: -24 °C
• transition temp: flash point 91 °C
• solubility: 1000 g/L
• density: 1.03 g/cm³ at 20 °C
• storage temp.: 2-30°C
• InChI: 1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3
• InChI key: SECXISVLQFMRJM-UHFFFAOYSA-N

Description

Application

• Novel transdermal bioadhesive surfactant-based system for release and solubility improvement of antimalarial drugs artemether-lumefantrine: This study utilizes 1-Methyl-2-pyrrolidone (NMP) as a high-purity solvent in the formulation of a transdermal bioadhesive system, enhancing the solubility and delivery of antimalarial drugs. The application highlights NMP′s role in pharmaceutical formulations, particularly in improving drug efficacy and patient compliance (Volpe-Zanutto et al., 2021).

Analysis Note

Purity (GC): ≥ 99.5 %
Water: ≤ 0.05 %
Transmission (at 300 nm): ≥ 50 %
Transmission (at 325 nm): ≥ 90 %
Transmission (at 350 nm): ≥ 97 %
Transmission (at 400 nm): ≥ 99 %

Other Notes

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Legal Information

LICHROSOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS07,GHS08
• signalword: Danger
• hcodes: H315 - H319 - H335 - H360D
• pcodes: P202 - P261 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 1
• flash_point_f: 195.8 °F - Pensky-Martens closed cup
• flash_point_c: 91 °C - Pensky-Martens closed cup