554412

Tetrodotoxin, Citrate, Fugu sp.

• Synonym(s): TTx
• UNSPSC Code: 12352202
• NACRES: NA.51

Properties

• description: Merck USA index - 14, 9246
• Quality Level: 100
• assay: ≥98%
• form: solid
• storage condition: OK to freeze
• color: white
• solubility: H₂O: 1 mg/mL
• storage temp.: 2-8°C

Description

General description

Reversibly blocks Na⁺ channels, which are essential for the propagation of impulses in excitable membranes. Useful as a marker of Na⁺ channels in excitable tissues. Inhibits the release of glutamate via Na+-dependent glutamate transporter and prevents veratradine-induced intracellular Ca²⁺ accumulation (IC₅₀ = 63 nM).

Application

Tetrodotoxin, Fugu sp., CAS 18660-81-6, is a reversible blocker of Na+ channels. Inhibits the release of glutamate via Na+-dependent glutamate transporter.

Biochem/physiol Actions

Target IC₅₀:63 nM Iinhibiting the release of glutamate via Na+-dependent glutamate transporter and prevents veratradine-induced intracellular Ca2+ accumulation

Physical form

Crystalline solid. Contains sodium citrate.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Activity is destroyed if exposed to alkaline or strongly acidic conditions.

Other Notes

Not available for sale outside of the United States.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H300
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 1 Oral
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3