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Streptozotocin

An N-nitroso-containing diabetogenic compound that acts as a nitric oxide donor in pancreatic islets. An antibiotic effective against Gram-negative bacteria. Causes DNA alkylation and DNA strand breaks in pancreatic islet cells.

Synonym(s):

Streptozotocin, 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose

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About This Item

Empirical Formula (Hill Notation):
C8H15N3O7
CAS Number:
18883-66-4
Molecular Weight:
265.22
MDL number:
MFCD00006607
UNSPSC Code:
12352103

Quality Level

100

assay

≥95% (HPLC)

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white to pale yellow

solubility

water: soluble

cation traces

heavy metals: ≤5 ppm

shipped in

ambient

storage temp.

−20°C

InChI

1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1

InChI key

ZSJLQEPLLKMAKR-GKHCUFPYSA-N

General description

An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets. An antibiotic effective against gram-negative bacteria. Causes DNA alkylation and DNA strand breaks in pancreatic islet cells. A diabetogenic agent.
An N-nitroso-containing diabetogenic compound that acts as a nitric oxide donor in pancreatic islets. An antibiotic effective against Gram-negative bacteria. Causes DNA alkylation and DNA strand breaks in pancreatic islet cells.

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstitution

Unstable in solution; reconstitute just prior to use. Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Kroncke, K.D., et al. 1995. Biol. Chem. Hoppe Seyler376, 179.
Kwon, N.S., et al. 1994. FASEB J.8, 529.
Rasschaert, J., et al. 1992. Endocrinology130, 3522.
Bennett, R.A. and Pegg, A.E. 1981. Cancer Res.41, 2786.
Yamamoto, H., et al. 1981. Nature294, 284.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameHealth hazard
GHS02,GHS08

signalword

Warning

Hazard Classifications

Carc. 2 - Flam. Sol. 2 - Muta. 2

Storage Class

4.1B - Flammable solid hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Qin Jiang et al.
The Journal of clinical investigation, 130(7), 3833-3847 (2020-04-29)
Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults. Vascular pericyte degeneration is the predominant clinical manifestation of DR, yet the mechanism governing pericyte degeneration is poorly understood. Circular RNAs (circRNAs) play important roles in multiple biological
Dezhi Chen et al.
Molecular medicine reports, 23(2) (2020-12-15)
Diabetic cardiomyopathy (DCM) is one of the primary complications of the cardiovascular system due to diabetes‑induced metabolic injury. The present study investigated the autophagy‑associated regulatory mechanisms of long non‑coding RNAs in cardiac pathological changes in diabetes mellitus (DM). Streptozotocin (STZ)‑induced
Zhongkun Ren et al.
Molecular medicine reports, 21(6), 2475-2483 (2020-04-03)
Epigallocatechin-3-gallate (EGCG) is beneficial for inhibiting dyslipidemia and reducing hyperlipidemic risk. The purpose of the present study was to investigate the glycolipid regulatory effects and potential mechanisms of EGCG in a high‑fat diet and streptozotocin‑induced type 2 diabetes mellitus (T2DM) mouse model.

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