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613550

Sigma-Aldrich

TMEM16A Activator, Eact

The TMEM16A Activator, Eact modulates the biological activity of TMEM16A. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

Synonym(s):

TMEM16A Activator, Eact, ANO1 Activator, Eact, 3,4,5-trimethoxy-N-(2-methoxyethyl)-N-(4-phenylthiazol-2-yl)benzamide, TMEM16A Activator, Eact

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100 μG
$691.00

$691.00


Estimated to ship onMarch 23, 2025



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100 μG
$691.00

About This Item

Empirical Formula (Hill Notation):
C22H24N2O5S
CAS Number:
Molecular Weight:
428.50
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

$691.00


Estimated to ship onMarch 23, 2025


Quality Level

assay

≥98% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 100 mg/mL, clear, colorless

shipped in

ambient

storage temp.

2-8°C

SMILES string

[s]1c(nc(c1)c3ccccc3)N(CCOC)C(=O)c2cc(c(c(c2)OC)OC)OC

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clone

5C6, monoclonal

clone

polyclonal

clone

polyclonal

clone

16C2, monoclonal

Gene Information

human ... VASP(7408)

Gene Information

human ... VASP(7408)
mouse ... Vasp(22323)
rat ... Vasp(361517)

Gene Information

-

Gene Information

-

species reactivity

human, mouse

species reactivity

mouse, human, rat

species reactivity

human

species reactivity

mouse, human

biological source

mouse

biological source

rabbit

biological source

rabbit

biological source

mouse

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

General description

An N-aroylaminothiazole that strongly activates TMEM16A (ANO1) calcium-activated chloride channel (CaCC) at 0 Ca2+ concentration (Ca2+ independent), with the capability of producing large and sustained CaCC Cl-1 currents (EC50 = 3 µM) in TMEM16A-expressing Fisher Rat Thyroid (FRT) Cells without elevation of cytoplasmic Ca2+ level, and in human A253 cells. Shown to increase CaCC conductance in human salivary and airway submucosal gland epithelial cells, IL-4 treated bronchial cells, and stimulated submucosal gland secretion in human bronchi and smooth muscle contraction in mouse intestine. Activation effect can be abolished by the addition of a TMEM16A inhibitor T16A-A01 at 10 µM in TMEM16A-transfected cells and in cultures of human salivary gland and IL-4-treated bronchial epithelia, but not in intestine. Does not affect CFTR Cl- conductance or ENaC Na+ conductance.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Namkung, W., et al. 2011. FASEB J.25, 4048.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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