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AB1593

Sigma-Aldrich

Anti-Amyloid Precursor Protein Antibody, a.a. 44-63

serum, Chemicon®

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Synonym(s):
APP
eCl@ss:
32160702
NACRES:
NA.41

biological source

goat

Quality Level

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
immunofluorescence: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... APP(351)

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This Item
AB5076AB5352AB5300
Sigma-Aldrich

AB5076

Anti-Amyloid Antibody, β 1-40/42

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

biological source

goat

biological source

rabbit

biological source

rabbit

biological source

rabbit

technique(s)

ELISA: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunofluorescence: suitable, western blot: suitable

technique(s)

ELISA: suitable, immunohistochemistry: suitable, western blot: suitable

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

immunoprecipitation (IP): suitable, western blot: suitable

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

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Specificity

Recognizes amyloid precursor protein (APP). In Alzheimer′s disease, this protein is broken down and releases the 12 amino acid b-amyloid protein that is found in senile plaques and vessels.

The amyloid precursor protein is the subject of intensive investigations to determine how this protein is broken down abnormally in Alzheimer′s disease to give rise to the b-amyloid protein which is present in senile plaques and vessels. This antiserum has been shown to be immunoreactive to the immunizing peptide by ELISA. The antiserum will immunolabel dystrophic neurites in senile plaques in both formalin-fixed paraffin sections and paraformaldehyde fixed frozen sections from Alzheimer′s brain.

This antiserum should be a valuable tool for scientist and neuropathologists who study the role of amyloid in Alzheimer′s′s disease.

Immunogen

Epitope: a.a. 44-63
Peptide to the N-terminal region (amino acids 44-63) of the APP protein.

Application

Anti-Amyloid Precursor Protein Antibody, a.a. 44-63 is an antibody against Amyloid Precursor Protein for use in ELISA, IF, WB, IH, IH(P).
Immunoblotting: 1:1,000

Immunofluorescence

Immunohistochemistry

Formalin fixed paraffin embedded tissue:1:50-1:100

4% paraformaldehyde fixed frozen sections: 1:2,500-1:5,000

ELISA: 1:1,500 against immunogen peptide

Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases

Physical form

Goat antiserum. Liquid with 0.1% Sodium Azide

Storage and Stability

Store at -20ºC in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Grant T Corbett et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(27), 8445-8450 (2015-06-17)
Amyloid precursor protein (APP) derivative β-amyloid (Aβ) plays an important role in the pathogenesis of Alzheimer's disease (AD). Sequential proteolysis of APP by β-secretase and γ-secretase generates Aβ. Conversely, the α-secretase "a disintegrin and metalloproteinase" 10 (ADAM10) cleaves APP within

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