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AB5888

Sigma-Aldrich

Anti-NOGO A Antibody

Chemicon®, from rabbit

Synonym(s):

Neurite outgrowth inihibitor A

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, human, rat

manufacturer/tradename

Chemicon®

technique(s)

western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Rtn4(68585)

General description

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified

Specificity

Cat. # AB5888 is specific to NOGO A. It does not recognize NOGO B or NOGO C.
Reactivity with other species has not been tested.

Application

Anti-NOGO A Antibody detects level of NOGO A & has been published & validated for use in WB.

Quality

Routinely tested on mouse brain lysate

Target description

Theoretical MW is approx. 126 kDa however literature reports observed molecular weight to be 205 kDa to 220 kDa

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Giuseppe Vaccaro et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 42(20), 4087-4100 (2022-04-20)
Nogo-66 receptors (NgR1-3) are glycosylphosphatidyl inositol-linked proteins that belong to the leucine-rich repeat superfamily. Through binding to myelin-associated inhibitors, NgRs contribute to the inhibition of axonal regeneration after spinal cord injury. Their role in limiting synaptic plasticity and axonal outgrowth
Feng Tan et al.
Experimental and therapeutic medicine, 16(6), 4943-4950 (2018-12-14)
Electroacupuncture (EA) may stimulate neurogenesis in animal models of ischemic stroke; however, the associated mechanisms are not clear. The present study aimed to evaluate the neurogenesis efficacy of EA on ischemic stroke and the underlying associated mechanisms. A model of
Ryan L O'Hare Doig et al.
BMC neuroscience, 18(1), 62-62 (2017-08-16)
Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are associated with metabolic and structural changes, but it is not
María Nazareth González-Alvarado et al.
Glia, 70(3), 522-535 (2021-11-18)
Recently, oligodendrocytes (Ol) have been attributed potential immunomodulatory effects. Yet, the exact mode of interaction with pathogenic CNS infiltrating lymphocytes remains unclear. Here, we attempt to dissect mechanisms of Ol modulation during neuroinflammation and characterize the interaction of Ol with
Jae Young Lee et al.
Scientific reports, 7(1), 8958-8958 (2017-08-23)
Axo-glial units are highly organised microstructures propagating saltatory conduction and are disrupted during multiple sclerosis (MS). Nogo receptor 1 (NgR1) has been suggested to govern axonal damage during the progression of disease in the MS-like mouse model, experimental autoimmune encephalomyelitis

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